Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers

Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2020, Volume: 56, Number: 5, Pages: 855-860 Pages count : 6 DOI: 10.1007/s10600-020-03169-x

Tags

caffeine; eudesmanolides; methylenelactones; Michael reaction

Authors

Reshetnikov D.V. ¹ , Patrushev S.S. ^1,2 , Shults E.E. ¹

Affiliations

1	(Scopus) N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 9 Prosp. Akad. Lavren?eva, Novosibirsk, 630090, Russian Federation
2	(Scopus) Novosibirsk State University, 1 Pirogova St., Novosibirsk, 630090, Russian Federation

8-(Aminoalkylamino)caffeine or 8-(piperazinyl)caffeine were formed in high yields by reacting 8-bromo- or 8-chlorocaffeine with linear and cyclic diamines using microwave-assisted organic synthesis. These amines were highly reactive in Michael reactions with sesquiterpene lactones containing active methylene groups. Conjugates with caffeine and eudesmanolide moieties bonded by a N-containing linker were synthesized. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Reshetnikov D.V. , Patrushev S.S. , Shults E.E.
Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers
Chemistry of Natural Compounds. 2020. V.56. N5. P.855-860. DOI: 10.1007/s10600-020-03169-x WOS Scopus РИНЦ

Published print:	Sep 1, 2020
Published online:	Sep 16, 2020

Web of science	WOS:000571091800008
Scopus	2-s2.0-85090943791
Elibrary	45289038
OpenAlex	W3088239964