Synthesis and biological activity of heterocyclic borneol derivatives

Synthesis and biological activity of heterocyclic borneol derivatives Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353

Output data

Year: 2017, Volume: 53, Number: 3, Pages: 371-377 Pages count : 7 DOI: 10.1007/s10593-017-2063-3

Tags

1H-benzimidazole-2-thiol; benzoxazole-2-thiol; benzthiazole-2-thiol; (-)-borneol; analgesic activity; antiulcer activity; antiviral activity

Authors

Sokolova Anastasiya S. ^1,2 , Yarovaya Olga I. ^1,2 , Shtro Anna A. ³ , Borisova Marina S. ¹ , Morozova Ekaterina A. ¹ , Tolstikova Tatyana G. ¹ , Zarubaev Vladimir V. ³ , Salakhutdinov Nariman F. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, 9 Lavrentiev Ave, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, 2 Pirogova St, Novosibirsk 630090, Russia
3	(Данные Web of science) Res Inst Influenza, Dept Chemotherapy, 15-17 Prof Popova St, St Petersburg 197376, Russia

A series of novel heterocyclic derivatives of (-)-borneol has been prepared by the interaction of (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]-heptan-2-yl 2-chloroacetate and (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 3-chloropropanoate with different N- and S-nucleophiles. The obtained products were screened for antiviral, antiulcer, and analgesic activity.

Sokolova A.S. , Yarovaya O.I. , Shtro A.A. , Borisova M.S. , Morozova E.A. , Tolstikova T.G. , Zarubaev V.V. , Salakhutdinov N.F.
Synthesis and biological activity of heterocyclic borneol derivatives
Chemistry of Heterocyclic Compounds. 2017. V.53. N3. P.371-377. DOI: 10.1007/s10593-017-2063-3 WOS Scopus РИНЦ

Published print:	Mar 1, 2017
Published online:	Apr 24, 2017

Web of science	WOS:000400545300017
Scopus	2-s2.0-85018809423
Elibrary	31038498
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