Supramolecular Systems for the Delivery of the Molecules of Medicinal Substances Based on Water-Soluble Plant Metabolites. Physicochemical, Pharmacological Properties and the Features of Mechanochemical Preparation

Supramolecular Systems for the Delivery of the Molecules of Medicinal Substances Based on Water-Soluble Plant Metabolites. Physicochemical, Pharmacological Properties and the Features of Mechanochemical Preparation Full article

Journal

CHEMISTRY FOR SUSTAINABLE DEVELOPMENT
ISSN: 1023-8603

Output data

Year: 2019, Volume: 27, Number: 3, Pages: 206-216 Pages count : 11 DOI: 10.15372/CSD2019129

Tags

drug delivery systems; mechanochemistry; polysaccharides; arabinogalactan; glycyrrhizic acid; saponins; vesicular systems; intermolecular complexes; membrane permeability; pharmacokinetic characteristics; bioavailability; toxicity; pharmacological action

Authors

Dushkin A.V. ¹ , Meteleva E.S. ¹ , Tolstikova T.G. ² , Khvostov M.V. ^2,3 , Polyakov N.E. ^1,4 , Lyakhov N.Z. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Inst Solid State Chem & Mechanochem, Siberian Branch, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Sci, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk, Russia
3	(Данные Web of science) Novosibirsk State Univ, Novosibirsk, Russia
4	(Данные Web of science) Russian Acad Sci, Inst Chem Kinet & Combust, Siberian Branch, Novosibirsk, Russia

A brief review summarizes the results of integrated pharmacological and physicochemical studies carried out in the Russian Academy of Sciences, focused on the supramolecular systems for the delivery of the molecules of medicinal substances based on water-soluble plant metabolites - polysaccharides and glycyrrhizic acid, as well as its derivatives. The promising potential of the development of medicines, dietary supplements and plant protection products of increased efficiency and safety is shown. The advantages of the solid-phase mechanochemical technology for obtaining water-soluble compositions of poorly soluble drugs are demonstrated.

Dushkin A.V. , Meteleva E.S. , Tolstikova T.G. , Khvostov M.V. , Polyakov N.E. , Lyakhov N.Z.
Supramolecular Systems for the Delivery of the Molecules of Medicinal Substances Based on Water-Soluble Plant Metabolites. Physicochemical, Pharmacological Properties and the Features of Mechanochemical Preparation
CHEMISTRY FOR SUSTAINABLE DEVELOPMENT. 2019. V.27. N3. P.206-216. DOI: 10.15372/CSD2019129 WOS

Душкин А.В. , Метелева Е.С. , Толстикова Т.Г. , Хвостов М.В. , Поляков Н.Е. , Ляхов Н.З.
Супрамолекулярные системы доставки молекул лекарственных веществ на основе водорастворимых растительных метаболитов. физико-химические, фармакологические свойства и особенности механохимического получения
ХИМИЯ В ИНТЕРЕСАХ УСТОЙЧИВОГО РАЗВИТИЯ. 2019. Т.27. №3. С.233-244. DOI: 10.15372/KhUR2019129 РИНЦ

Web of science	WOS:000571382300001
OpenAlex	W4256190428