Abstract: The review examines the pharmacological effects of 4-(hydroxyethyl)phenol (p-tyrosol) and its metabolite 2-hydroxytyrosol in acute ischemic disorders of the cardiovascular system and cerebral stroke. The antithrombotic, antioxidant, anti-inflammatory and antiarrhythmic activity of this compound is discussed in detail, its antimicrobial, anti-cancer and anti-metastases effects are noted. p-Tyrosol contributes to the creation of a new vascular system in the affected area (neoangiogesis), which leads not only to the restoration of blood supply in the organ affected by ischemia, but also improves geodynamics in the whole body. Studies in animals have proven the effectiveness of parenteral administration of p-tyrosol in the preoperative period of exacerbation of heart ischemia and stroke of the brain. The use of this substance leads in most cases to arresting arrhythmias and thrombosis, has a beneficial effect on the nervous system, which generally helps to reduce the area of damage to the heart and other organs with ischemia, significantly increases the number of surviving animals. The positive effect of plants containing p-tyrosol and its derivatives on the human cardiovascular system is considered, along with pharmacokinetics and the routes of the introduction of these phenolic compounds into the organism at different stages of ischemia.

Cite: Krysin A.P. , Sorokina I. , Shults E.E.
Cardioprotective Effect of p-Tyrosol in the Acute Period of Cardiovascular and Cerebral Ischemia
CHEMISTRY FOR SUSTAINABLE DEVELOPMENT. 2019. V.27. N4. P.328-335. DOI: 10.15372/CSD2019147 WOS

ArticleLinkType.TRANSLATED_TO_ORIGINAL: Крысин А.П. , Сорокина И.В. , Шульц Э.Э.
Кардиопротекторное действие п-тирозола в острый период сердечно-сосудистой и церебральной ишемии
ХИМИЯ В ИНТЕРЕСАХ УСТОЙЧИВОГО РАЗВИТИЯ. 2019. Т.27. №4. С.365-372. DOI: 10.15372/KhUR2019147 РИНЦ

Identifiers:

Web of science	WOS:000573425300003
OpenAlex	W4247191808

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