New insight into the mechanism of drug release from poly(D,l-lactide) film by electron paramagnetic resonance

New insight into the mechanism of drug release from poly(D,l-lactide) film by electron paramagnetic resonance Full article

Journal

Polymers
ISSN: 2073-4360

Output data

Year: 2020, Volume: 12, Number: 12, Article number : 3046, Pages count : 21 DOI: 10.3390/polym12123046

Tags

Electron paramagnetic resonance; Mathematical model of the release kinetics; Mechanism of drug release; Paramagnetic dopants; Poly(D,L-lactide) films

Authors

Chumakova Natalia A. ¹ , Golubeva Elena N. ¹ , Kuzin Sergey V. ¹ , Ivanova Tatiana A. ¹ , Grigoriev Igor A. ² , Kostjuk Sergey V. ^3,4,5 , Melnikov Mikhail Ya. ¹

Affiliations

1	Department of Chemistry, M.V.Lomonosov Moscow State University, Leninskiye Gory, 1/3, Moscow, 119991, Russian Federation
2	Vorozhtsov Novosibirsk Institute of Organic Chemistry Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk, 630090, Russian Federation
3	Department of Chemistry, Belarusian State University, Leningradskaya Str. 14, Minsk, 220006, Belarus
4	Research Institute for Physical Chemical Problems, Belarusian State University, 14 Leningradskaya Str., Minsk, 220006, Belarus
5	Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation

A novel approach based on convolution of the electron paramagnetic resonance (EPR) spectra was used for quantitative study of the release kinetics of paramagnetic dopants from poly(D,L-lactide) films. A non-monotonic dependence of the release rate on time was reliably recorded. The release regularities were compared with the dynamics of polymer structure changes determined by EPR, SEM, and optic microscopy. The data obtained allow for the conclusion that the main factor governing dopant release is the formation of pores connected with the surface. In contrast, the contribution of the dopant diffusion through the polymer matrix is negligible. The dopant release can be divided into two phases: release through surface pores, which are partially closed with time, and release through pores initially formed inside the polymer matrix due to autocatalytic hydrolysis of the polymer and gradually connected to the surface of the sample. For some time, these processes co-occur. The mathematical model of the release kinetics based on pore formation is presented, describing the kinetics of release of various dopants from the polymer films of different thicknesses. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Chumakova N.A. , Golubeva E.N. , Kuzin S.V. , Ivanova T.A. , Grigoriev I.A. , Kostjuk S.V. , Melnikov M.Y.
New insight into the mechanism of drug release from poly(D,l-lactide) film by electron paramagnetic resonance

Polymers. 2020. V.12. N12. 3046 :1-21. DOI: 10.3390/polym12123046 WOS Scopus РИНЦ

Full text from publisher

Published online:

Dec 18, 2020

Web of science	WOS:000603095800001
Scopus	2-s2.0-85098072260
Elibrary	45057343
OpenAlex	W3110888745