FFA1 (GPR40) Receptor Agonists Based on Phenylpropanoic Acid as Hypoglycemic Agents: Structure–Activity Relationship

FFA1 (GPR40) Receptor Agonists Based on Phenylpropanoic Acid as Hypoglycemic Agents: Structure–Activity Relationship Full article

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Output data

Year: 2020, Volume: 46, Number: 6, Pages: 972-988 Pages count : 17 DOI: 10.1134/S1068162020060151

Tags

FFA1; FFA1 receptor agonists; GPR40; hypoglycemic activity; phenylpropanoic acid; type 2 diabetes mellitus

Authors

Kuranov S.O. ¹ , Luzina O.A. ¹ , Salakhutdinov N.F. ¹

Affiliations

1	Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation

Abstract: Free fatty acid receptor-1 (FFA1) agonists have been considered for a long time as a potentially new class for the treatment of type 2 diabetes mellitus. Phenylpropanoic acid is the preferred scaffold in the development of FFA1 receptor agonists. This review analyzes the effect of structural fragments of phenylpropanoic acid-based agonists on receptor affinity, selectivity, biocompatibility, and metabolic stability. Current trends in the design of FFA1 receptor agonists are discussed. © 2020, Pleiades Publishing, Ltd.

Kuranov S.O. , Luzina O.A. , Salakhutdinov N.F.
FFA1 (GPR40) Receptor Agonists Based on Phenylpropanoic Acid as Hypoglycemic Agents: Structure–Activity Relationship
Russian Journal of Bioorganic Chemistry. 2020. V.46. N6. P.972-988. DOI: 10.1134/S1068162020060151 WOS Scopus РИНЦ

Published print:	Nov 1, 2020
Published online:	Dec 28, 2020

Web of science	WOS:000603326600004
Scopus	2-s2.0-85098130272
Elibrary	45059962
OpenAlex	W3116915721