Synthesis of Substituted 2-(Thiophen-2-yl)-1H-imidazol-1-ols

Synthesis of Substituted 2-(Thiophen-2-yl)-1H-imidazol-1-ols Full article

Journal

Russian Journal of Organic Chemistry
ISSN: 1070-4280 , E-ISSN: 1608-3393

Output data

Year: 2017, Volume: 53, Number: 2, Pages: 236-239 Pages count : 4 DOI: 10.1134/S1070428017020166

Authors

Os'kina I.A. ¹ , Tikhonov A.Ya. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Pr Akad Lavrenteva 9, Novosibirsk 630090, Russia

Substituted 2-(thiophen-2-yl)-1H-imidazol-1-ols were synthesized by cyclization of the corresponding alpha-thienyl nitrones in alkaline medium. alpha-Thienyl nitrones were obtained by reaction of N-(1-hydroxyimine-1-R-propan-2-yl)hydroxylamines with thiophene-2-carbaldehyde in methanol. At boiling alpha-thienyl nitrones in methanol in the presence of sodium methylate 5-aryl(hetaryl)-2-(thiophen-2-yl)-1H-imidazol-1-ols are formed chemoselectively.

Os'kina I.A. , Tikhonov A.Y.
Synthesis of Substituted 2-(Thiophen-2-yl)-1H-imidazol-1-ols
Russian Journal of Organic Chemistry. 2017. V.53. N2. P.236-239. DOI: 10.1134/S1070428017020166 WOS Scopus РИНЦ

Оськина И.А. , Тихонов А.Я.
Синтез замещённых 2-(тиофен-2-ил)-1н-имидазол-1-олов
Журнал органической химии (RUSS J ORG CHEM+). 2017. Т.53. №2. С.242-245. РИНЦ

Published print:	Feb 1, 2017
Published online:	Apr 18, 2017

Web of science	WOS:000399781000016
Scopus	2-s2.0-85017501244
Elibrary	29500506
OpenAlex	W2605665553