Composition and Bioactivity of Lipophilic Metabolites from Needles and Twigs of Korean and Siberian Pines (Pinus koraiensis Siebold & Zucc. and Pinus sibirica Du Tour)

Composition and Bioactivity of Lipophilic Metabolites from Needles and Twigs of Korean and Siberian Pines (Pinus koraiensis Siebold & Zucc. and Pinus sibirica Du Tour) Full article

Journal

Chemistry and Biodiversity
ISSN: 1612-1872 , E-ISSN: 1612-1880

Output data

Year: 2017, Volume: 14, Number: 2, Article number : e1600203, Pages count : DOI: 10.1002/cbdv.201600203

Tags

Pinus koraiensis; Pinus sibirica; Diterpenoids; Fatty acids

Authors

Shpatov Alexander V. ¹ , Popov Sergey A. ¹ , Salnikova Olga I. ¹ , Kukina Tatyana P. ¹ , Shmidt Emma N. ¹ , Um Byung Hun ²

Affiliations

1	(Данные Web of science) Novosibirsk Inst Organ Chem, Acad Lavrentyev Ave 9, RU-630090 Novosibirsk, Russia
2	(Данные Web of science) Korea Inst Sci & Technol, Gangneung Inst, Nat Prod Res Ctr, 290 Daejeon Dong, Kangnung 210340, Gangwon Do, South Korea

Lipophilic extractive metabolites in different parts of the shoot system (needles and defoliated twigs) of Korean pine, Pinus koraiensis, and Siberian pine, Pinus sibirica, were studied by GC/MS. Korean pine needles comprised mainly bornyl p-coumarate, heterocyclic 15-O-functionalized labdane type acids (lambertianic acid), 10-nonacosanol, sterols and their esters. While Siberian pine needles contained less bornyl p-coumarate, lambertianic acid, sterols and their esters, but were richer in other 15-O-functionalized labdane type acids. The major components of the twig extract of P. koraiensis were lambertianic acid, abietane and isopimarane type acids, cembrane type alcohols, 8-O-functionalized labdanoids, sterols, sterol esters, and acylglycerols. The same extract of P. sibirica differed in larger amounts of other 15-O-functionalized labdane type acids and pinolenic acid glycerides, but in less quantities of cembranoids and 8-O-functionalized labdanoids. The labdane type pinusolic acid was detected for the first time in Korean pine. P. koraiensis was found to be unique in the genus for an ability to synthesize phyllocladane diterpenoids. The content of bound (5)-unsaturated polymethylene-interrupted fatty acids in the twig extracts of the both pines was similar or superior to that in their seed oil. Among the pines' metabolites tested isocembrol was strongest in inhibition of both -glucosidase (IC50 2.9 g/ml) and NO production in activated macrophages (IC50 3.6 g/ml).

Shpatov A.V. , Popov S.A. , Salnikova O.I. , Kukina T.P. , Shmidt E.N. , Um B.H.
Composition and Bioactivity of Lipophilic Metabolites from Needles and Twigs of Korean and Siberian Pines (Pinus koraiensis Siebold & Zucc. and Pinus sibirica Du Tour)
Chemistry and Biodiversity. 2017. V.14. N2. e1600203 . DOI: 10.1002/cbdv.201600203 WOS Scopus РИНЦ

Published print:	Feb 1, 2017
Published online:	Feb 4, 2017

Web of science	WOS:000394544100004
Scopus	2-s2.0-85012931935
Elibrary	29483698
OpenAlex	W2482230669