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Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins Full article

Journal Medicinal Chemistry Research
ISSN: 1054-2523 , E-ISSN: 1554-8120
Output data Year: 2017, Volume: 26, Number: 2, Pages: 397-404 Pages count : 8 DOI: 10.1007/s00044-016-1759-8
Tags Varacin; Polysulfide compounds; Oncology; Cytotoxicity; Cancer preventive activity
Authors Kuzmich Alexandra S. 1 , Khomenko Tatyana M. 2,3 , Fedorov Sergey N. 1 , Makarieva Tatyana N. 1 , Shubina Larisa K. 1 , Komarova Nina I. 2 , Korchagina Dina V. 2 , Rybalova Tatyana V. 2 , Volcho Konstantin P. 2,3 , Salakhutdinov Nariman F. 2,3
Affiliations
1 (Данные Web of science) Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Prospect 100 Let Vladivostoku 159, Vladivostok 690022, Russia
2 (Данные Web of science) Novosibirsk Organ Chem Inst, Pr Lavrentieva 9, Novosibirsk 630090, Russia
3 (Данные Web of science) Novosibirsk State Univ, Pirogova 2, Novosibirsk 630090, Russia

Abstract: The cytotoxic and cancer preventive activities of synthetic analogs of natural varacins with polysulfide groups were studied. Presence of a sulfoxide group was found to have no significant effect on the cytotoxicity of these compounds. At the same time, this group is important for inhibition of colony formation of tumor cells treated with tumor promoter thus demonstrating cancer preventive activity. The most promising compound appears to be a synthetic varacin C analog, sulfoxide 10a, which exhibits the cancer preventive activity at dose into 100 times lower than its cytotoxic concentrations.
Cite: Kuzmich A.S. , Khomenko T.M. , Fedorov S.N. , Makarieva T.N. , Shubina L.K. , Komarova N.I. , Korchagina D.V. , Rybalova T.V. , Volcho K.P. , Salakhutdinov N.F.
Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins
Medicinal Chemistry Research. 2017. V.26. N2. P.397-404. DOI: 10.1007/s00044-016-1759-8 WOS Scopus РИНЦ
Dates:
Published online: Dec 16, 2016
Published print: Feb 1, 2017
Identifiers:
Web of science WOS:000392618400011
Scopus 2-s2.0-85006094837
Elibrary 29474478
OpenAlex W2565116146
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