Effects of insulin-like growth factor 1 on pathologic processes in the cuprizone model of multiple sclerosis

Effects of insulin-like growth factor 1 on pathologic processes in the cuprizone model of multiple sclerosis Full article

Journal

Journal of Physics: Conference Series
ISSN: 1742-6588 , E-ISSN: 1742-6596

Output data

Year: 2017, Volume: 886, Article number : UNSP 012005, Pages count : DOI: 10.1088/1742-6596/886/1/012005

Authors

Fedorishin D. ¹ , Sorokina I. ² , Tolstikova T. ² , Akulov A. ^1,3 , Glazacheva V. ¹ , Nemirovich-Danchenko N. ¹ , Khodanovich M. ¹ , Yarnykh V. ^1,4

Affiliations

1	(Данные Web of science) Tomsk State Univ, Res Inst Biol & Biophys, Tomsk, Russia
2	(Данные Web of science) Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk, Russia
3	(Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia
4	(Данные Web of science) Univ Washington, Dept Radiol, Vasc Imaging Lab, Seattle, WA 98195 USA

The study aims to evaluate the effect of insulin-like growth factor 1 (IGF-1) on the demyelination and astrogliosis using the cuprizone murine model. Demyelination was induced in 14 adult male mice by 0.3% cuprizone in drinking water. Five animals from the cuprizonetreated group received subcutaneous injections of IGF-1. Seven animals were used as a control group. The extent of demyelination was evaluated as a decrease in the size of the corpus callosum on T2-weighted images that were received using an 11.7T animal MRI scanner. Brain sections were immunohistochemically stained for glial fibrillary acidic protein (GFAP), a marker of astrocytes. It was revealed that the cuprizone caused extensive demyelination and astroglyosis. IGF-1 treatment restored the size of the corpus callosum and the number of astrocytes in the corpus callosum and the anterior commissure to the control level.

Fedorishin D. , Sorokina I. , Tolstikova T. , Akulov A. , Glazacheva V. , Nemirovich-Danchenko N. , Khodanovich M. , Yarnykh V.
Effects of insulin-like growth factor 1 on pathologic processes in the cuprizone model of multiple sclerosis

Journal of Physics: Conference Series. 2017. V.886. UNSP 012005 . DOI: 10.1088/1742-6596/886/1/012005 WOS Scopus РИНЦ

Full text from publisher

Published print:	Aug 1, 2017
Published online:	Aug 29, 2017

Web of science	WOS:000437893600006
Scopus	2-s2.0-85029595173
Elibrary	31062744
OpenAlex	W2753582285