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Usnic Acid Derivatives Are Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Full article

Journal Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620
Output data Year: 2017, Volume: 43, Number: 1, Pages: 84-90 Pages count : 7 DOI: 10.1134/S1068162017010125
Tags tyrosyl-DNA phosphodiesterase 1; tyrosyl-DNA phosphodiesterase 1 inhibitors; usnic acid
Authors Zakharenko A.L. 1 , Luzina O.A. 2 , Sokolov D.N. 2 , Zakharova O.D. 1 , Rakhmanova M.E. 3 , Chepanova A.A. 4 , Dyrkheeva N.S. 1 , Lavrik O.I. 1,3,4 , Salakhutdinov N.F. 2,3
Affiliations
1 (Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia
2 (Данные Web of science) Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
3 (Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
4 (Данные Web of science) Altai State Univ, Barnaul 656049, Russia

Abstract: The synthesis of (+)-usnic acid derivatives is described. The derivatives contain one or two cyano groups, connected to the acetophenone fragment of dibenzofuran core by linkers of different length and character, or some other modifications. The influence of these compounds on the activity of recombinant human tyrosyl-DNA phosphodiesterase 1 and MCF-7 tumor cells' viability has been estimated. The data indicate a distinct dependence of functional characteristics of the compounds on their structure.
Cite: Zakharenko A.L. , Luzina O.A. , Sokolov D.N. , Zakharova O.D. , Rakhmanova M.E. , Chepanova A.A. , Dyrkheeva N.S. , Lavrik O.I. , Salakhutdinov N.F.
Usnic Acid Derivatives Are Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1
Russian Journal of Bioorganic Chemistry. 2017. V.43. N1. P.84-90. DOI: 10.1134/S1068162017010125 WOS Scopus РИНЦ
Dates:
Published print: Jan 1, 2017
Published online: Feb 14, 2017
Identifiers:
Web of science WOS:000396423800012
Scopus 2-s2.0-85012864677
Elibrary 29486686
OpenAlex W2589050450
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