Simple and efficient process for large scale preparation of betulonic acid from birch bark extracts

Simple and efficient process for large scale preparation of betulonic acid from birch bark extracts Full article

Journal

Industrial Crops and Products
ISSN: 0926-6690 , E-ISSN: 1872-633X

Output data

Year: 2016, Volume: 92, Pages: 197-200 Pages count : 4 DOI: 10.1016/j.indcrop.2016.07.026

Tags

Betulonic acid; Betulin; Birch bark extraction; Extract oxidation

Authors

Popov Sergey A. ¹ , Kozlova Lyubov' P. ¹ , Kornaukhova Lyubov' M. ¹ , Shpatov Alexander V. ¹

Affiliations

1	(Данные Web of science) Novosibirsk Organ Chem Inst, Acad Lavrentyev Ave 9, Novosibirsk 630090, Russia

A bioactive triterpenoid betulonic acid is a valuable synthone for preparation of lupane- and oleanane-type derivatives with a wide spectrum of medical applications. A large-scale, cost-effective, and simple preparation of betulonic acid from birch (Betula pendula) bark is presented herein. The process includes four steps with the acid overall yield of 51% counting on betulin content in the extract and with the acid purity of 90% or more. The process can be employed for batch production of betulonic acid. (C) 2016 Elsevier B.V. All rights reserved.

Popov S.A. , Kozlova L.P. , Kornaukhova L.M. , Shpatov A.V.
Simple and efficient process for large scale preparation of betulonic acid from birch bark extracts
Industrial Crops and Products. 2016. V.92. P.197-200. DOI: 10.1016/j.indcrop.2016.07.026 WOS Scopus РИНЦ

Published print:

Dec 1, 2016

Web of science	WOS:000383821200023
Scopus	2-s2.0-84981276955
Elibrary	27134990
OpenAlex	W2515359892