Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats

Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats Full article

Journal

Therapeutic Delivery
ISSN: 2041-5990 , E-ISSN: 2041-6008

Output data

Year: 2021, Volume: 12, Number: 2, Pages: 119-131 Pages count : 13 DOI: 10.4155/tde-2020-0115

Tags

arabinogalactan; bioavailability; complexes; drug delivery; mechanochemistry; nifedipine

Authors

Khvostov Mikhail Vladimirovich ^1,2 , Chernonosov Alexander Anatolievich ³ , Borisov Sergey Alkisovich ¹ , Borisova Marina Sergeevna ¹ , Meteleva Elizaveta Sergeevna ⁴ , Evseenko Veronika Ivanovna ⁴ , Polyakov Nikolay Eduardovich ⁵ , Dushkin Alexander Valerievich ⁴ , Tolstikova Tatjana Genrihovna ^1,2

Affiliations

1	Laboratory of Pharmacological Research, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Novosibirsk, 630090, Russian Federation
2	Core Facility of Mass Spectrometric Analysis, Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, 630090, Russian Federation
3	Group of Mechanochemistry of Organic Substances, Institute of Solid State Chemistry and Mechanochemistry SB RAS, Novosibirsk, 630090, Russian Federation
4	V. Zelman Institute for the Medicine and Psychology, Novosibirsk State University, Novosibirsk, 630090, Russian Federation
5	Laboratory of Magnetic Phenomena, Institute of Chemical Kinetics and Combustion SB RAS, Novosibirsk, 630090, Russian Federation

Aim: Physicochemical and pharmacological study of the supramolecular inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). Materials & methods: The NF:AG complexes were obtained and their physicochemical properties were studied. Their hypotensive action and pharmacokinetic profiles were evaluated in rats with normal and elevated arterial blood pressure. Results: In both rat lines the NF:AG complex decreased the arterial blood pressure at a lower dose than free NF (1.75 mg/kg of NF in complex compared with 3.5 mg/kg of free NF) and has a better pharmacokinetic profile than free NF. Conclusion: The use of the NF:AG complex is an effective way to sufficiently enhance and hasten NF's hypotensive action. © 2021 Future Medicine Ltd.. All rights reserved.

Khvostov M.V. , Chernonosov A.A. , Borisov S.A. , Borisova M.S. , Meteleva E.S. , Evseenko V.I. , Polyakov N.E. , Dushkin A.V. , Tolstikova T.G.
Study of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats
Therapeutic Delivery. 2021. V.12. N2. P.119-131. DOI: 10.4155/tde-2020-0115 WOS Scopus

Web of science	WOS:000617900100001
Scopus	2-s2.0-85101294588
OpenAlex	W3127948190