(+)-Camphor and (−)-borneol derivatives as potential anti-orthopoxvirus agents

(+)-Camphor and (−)-borneol derivatives as potential anti-orthopoxvirus agents Full article

Journal

Archiv der Pharmazie
ISSN: 0365-6233

Output data

Year: 2021, Volume: 354, Number: 6, Article number : 2100038, Pages count : DOI: 10.1002/ardp.202100038

Tags

(+)-camphor; (−)-borneol; cowpox virus; ectromelia virus; vaccinia virus; variola virus

Authors

Sokolova A.S. ¹ , Kovaleva K.S. ¹ , Yarovaya O.I. ¹ , Bormotov N.I. ² , Shishkina L.N. ² , Serova O.A. ² , Sergeev A.A. ² , Agafonov A.P. ² , Maksuytov R.A. ² , Salakhutdinov N.F. ¹

Affiliations

1	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch Russian Academy of Sciences, Novosibirsk, Russian Federation
2	State Research Centre of Virology and Biotechnology VECTOR, Rospotrebnadzor, Novosibirsk, Russian Federation

Although the World Health Organisation had announced that smallpox was eradicated over 40 years ago, the disease and other related pathogenic poxviruses such as monkeypox remain potential bioterrorist weapons and could also re-emerge as natural infections. We have previously reported (+)-camphor and (−)-borneol derivatives with an antiviral activity against the vaccinia virus. This virus is similar to the variola virus (VARV), the causative agent of smallpox, but can be studied at BSL-2 facilities. In the present study, we evaluated the antiviral activity of the most potent compounds against VARV, cowpox virus, and ectromelia virus (ECTV). Among the compounds tested, 4-bromo-Nʹ-((1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene)benzohydrazide 18 is the most effective compound against various orthopoxviruses, including VARV, with an EC50 value of 13.9 μM and a selectivity index of 206. Also, (+)-camphor thiosemicarbazone 9 was found to be active against VARV and ECTV. © 2021 Deutsche Pharmazeutische Gesellschaft

Sokolova A.S. , Kovaleva K.S. , Yarovaya O.I. , Bormotov N.I. , Shishkina L.N. , Serova O.A. , Sergeev A.A. , Agafonov A.P. , Maksuytov R.A. , Salakhutdinov N.F.
(+)-Camphor and (−)-borneol derivatives as potential anti-orthopoxvirus agents
Archiv der Pharmazie. 2021. V.354. N6. 2100038 . DOI: 10.1002/ardp.202100038 WOS Scopus РИНЦ

Published online:	Feb 19, 2021
Published print:	Jun 1, 2021

Web of science	WOS:000619540200001
Scopus	2-s2.0-85101002357
Elibrary	46753684
OpenAlex	W3132144403