Synthesis of 2,5-bis(spirocyclohexane)-substituted nitroxides: New spin labeling agents

Synthesis of 2,5-bis(spirocyclohexane)-substituted nitroxides: New spin labeling agents Full article

Journal

Tetrahedron
ISSN: 0040-4020

Output data

Year: 2021, Volume: 81, Article number : 131915, Pages count : DOI: 10.1016/j.tet.2020.131915

Tags

Nitroxide spin labels; Spiro-substituted nitroxides; EPR spectroscopy; Site-directed spin labeling; PELDOR

Authors

Polienko Yuliya F. ¹ , Kuprikova Natalia M. ¹ , Parkhomenko Dmitriy A. ¹ , Gatilov Yuriy ¹ , Chernyak Elena ¹ , Kirilyuk Igor A. ¹

Affiliations

1	(Данные Web of science) NN Vorozhtsov Novosibirsk Inst Organ Chem SB RAS, Pr Lavrentjeva 9, Novosibirsk 630090, Russia

The nitroxides with spirocyclic moieties adjacent to N-O group were shown to demonstrate longer spin echo dephasing times between 80 and 295 K than tetramethyl ones. New spin labels for site-directed spin labeling have been prepared from 2,5-bis(spirocyclohexane)-substituted nitroxides of pyrroline series. The labels synthesized contain terminal acetylene and iodoacetamide groups are analogous to those of tetramethyl type but have some advantages in reduction stability and relaxation rates. (C) 2020 Elsevier Ltd. All rights reserved.

Polienko Y.F. , Kuprikova N.M. , Parkhomenko D.A. , Gatilov Y. , Chernyak E. , Kirilyuk I.A.
Synthesis of 2,5-bis(spirocyclohexane)-substituted nitroxides: New spin labeling agents
Tetrahedron. 2021. V.81. 131915 . DOI: 10.1016/j.tet.2020.131915 WOS Scopus РИНЦ

Published print:

Feb 1, 2021

Web of science	WOS:000620932700015
Scopus	2-s2.0-85099159940
Elibrary	45017911
OpenAlex	W3115891443