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Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents Full article

Journal Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388
Output data Year: 2016, Volume: 52, Number: 5, Pages: 813-820 Pages count : 8 DOI: 10.1007/s10600-016-1785-2
Tags monoterpenes; thiophenecarboxaldehyde; clay; heterocyclic compounds; analgesic activity
Authors Pavlova A.V. 1 , Nazimova E.V. 1 , Mikhal'chenko O.S. 1 , Il'ina I.V. 1,2 , Korchagina D.V. 1 , Ardashov O.V. 1,2 , Morozova E.A. 1 , Tolstikova T.G. 1 , Volcho K.P. 1,2 , Salakhutdinov N.F. 1,2
Affiliations
1 (Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia
2 (Данные Web of science) Novosibirsk Natl Res State Univ, 2 Pirogova St, Novosibirsk 630090, Russia

Abstract: Hexahydro-2H-chromenes with thiophene fragments were synthesized via reactions of a p-menthane monoterpenoid diol with several thiophenecarboxaldehydes. Most of the synthesized compounds with an additional thiophene fragment displayed analgesic activity in vivo tests at a dose of 10 mg/kg. It was found that the activity in either an acetate-writhing test or a hot-plate test depended on the type and location of substituent in the heteroaromatic ring.
Cite: Pavlova A.V. , Nazimova E.V. , Mikhal'chenko O.S. , Il'ina I.V. , Korchagina D.V. , Ardashov O.V. , Morozova E.A. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents
Chemistry of Natural Compounds. 2016. V.52. N5. P.813-820. DOI: 10.1007/s10600-016-1785-2 WOS Scopus РИНЦ
Dates:
Published online: Aug 15, 2016
Published print: Sep 1, 2016
Identifiers:
Web of science WOS:000381974900010
Scopus 2-s2.0-85027945480
Elibrary 41782363
OpenAlex W2515890576
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