Ultrasensitive detection of inhaled organic aerosol particles by accelerator mass spectrometry

Ultrasensitive detection of inhaled organic aerosol particles by accelerator mass spectrometry Full article

Journal

Chemosphere
ISSN: 0045-6535 , E-ISSN: 1879-1298

Output data

Year: 2016, Volume: 159, Pages: 80-88 Pages count : DOI: 10.1016/j.chemosphere.2016.05.078

Tags

Organic aerosols; Low-dose inhalation; Polystyrene beads; Radiocarbon; Accelerator mass-spectrometry; Mice

Authors

Parkhomchuk E. V. ^1,2 , Gulevich D. G. ^1,2 , Taratayko A. I. ^1,3 , Baklanov A. M. ⁴ , Selivanova A. V. ^1,5 , Trubitsyna T. A. ⁵ , Voronova I. V. ¹ , Kalinkin P. N. ^1,2 , Okunev A. G. ^1,2 , Rastigeev S. A. ^1,6 , Reznikov V. A. ^1,3 , Semeykina V. S. ^1,2 , Sashkina K. A. ^1,2 , Parkhomchuk V. V. ^1,6

Affiliations

1	(Данные Web of science) Novosibirsk State Univ, Lab Radiocarbon Methods Anal, 2 Pirogova St, Novosibirsk 630090, Russia
2	(Данные Web of science) Boreskov Inst Catalysis SB RAS, 5 Lavrentieva St, Novosibirsk 630090, Russia
3	(Данные Web of science) NN Vorozhtsov Novosibirsk Inst Organ Chem SB RAS, 9 Lavrentieva St, Novosibirsk 630090, Russia
4	(Данные Web of science) Voevodsky Inst Chem Kinet & Combust SB RAS, 3 Inst Skaya St, Novosibirsk 630090, Russia
5	(Данные Web of science) JSC Tion, 20 Injenernaya Sr, Novosibirsk 630090, Russia
6	(Данные Web of science) Budker Inst Nucl Phys SB RAS, 11 Lavrentieva St, Novosibirsk 630090, Russia

Accelerator mass spectrometry (AMS) was shown to be applicable for studying the penetration of organic aerosols, inhaled by laboratory mice at ultra-low concentration ca. 10(3) cm(-3). We synthesized polystyrene (PS) beads, composed of radiocarbon-labeled styrene, for testing them as model organic aerosols. As a source of radiocarbon we used methyl alcohol with radioactivity. Radiolabeled polystyrene beads were obtained by emulsifier-free emulsion polymerization of synthesized C-14-styrene initiated by K2S2O8 in aqueous media. Aerosol particles were produced by pneumatic spraying of diluted C-14-PS latex. Mice inhaled C-14-PS aerosol consisting of the mix of 10(3) 225-nm particles per 1 cm(3) and 5.10(3) 225-nm particles per 1 cm(3) for 30 min every day during five days. Several millions of 225-nm particles deposited in the lungs and slowly excreted from them during two weeks of postexposure. Penetration of particles matter was also observed for liver, kidneys and brain, but not for a heart. (C) 2016 Elsevier Ltd. All rights reserved.

Parkhomchuk E.V. , Gulevich D.G. , Taratayko A.I. , Baklanov A.M. , Selivanova A.V. , Trubitsyna T.A. , Voronova I.V. , Kalinkin P.N. , Okunev A.G. , Rastigeev S.A. , Reznikov V.A. , Semeykina V.S. , Sashkina K.A. , Parkhomchuk V.V.
Ultrasensitive detection of inhaled organic aerosol particles by accelerator mass spectrometry
Chemosphere. 2016. V.159. P.80-88. DOI: 10.1016/j.chemosphere.2016.05.078 WOS Scopus РИНЦ

Published print:

Sep 1, 2016

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Scopus	2-s2.0-84973174909
Elibrary	27099970
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