Correlation of Metabolic Profiles of Plasma and Cerebrospinal Fluid of High-Grade Glioma Patients

Correlation of Metabolic Profiles of Plasma and Cerebrospinal Fluid of High-Grade Glioma Patients Full article

Journal

Metabolites
ISSN: 2218-1989

Output data

Year: 2021, Volume: 11, Number: 3, Article number : 133, Pages count : DOI: 10.3390/metabo11030133

Tags

glioma; metabolomics; liquid chromatography; tandem mass spectrometry; plasma; cerebrospinal fluid

Authors

Rogachev Artem D. ^1,2 , Alemasov Nikolay A. ³ , Ivanisenko Vladimir A. ³ , Ivanisenko Nikita ³ , Gaisler Evgeniy ¹ , Oleshko Olga S. ¹ , Cheresiz Sergey ¹ , Mishinov Sergey ⁴ , Stupak Vyacheslav V. ⁴ , Pokrovsky Andrey G. ¹

Affiliations

1	(Данные Web of science) Novosibirsk State Univ, V Zelman Inst Med & Psychol, Pirogov Str 2, Novosibirsk 630090, Russia
2	(Данные Web of science) NN Vorozhtsov Novosibirsk Inst Organ Chem, Acad Lavrentiev Ave 9, Novosibirsk 630090, Russia
3	(Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Acad Lavrentiev Ave 10, Novosibirsk 630090, Russia
4	(Данные Web of science) FSBI Novosibirsk Res Inst Traumatol & Orthoped, Frunze Str 17, Novosibirsk 630091, Russia

This work compares the metabolic profiles of plasma and the cerebrospinal fluid (CSF) of the patients with high-grade (III and IV) gliomas and the conditionally healthy controls using the wide-range targeted screening of low molecular metabolites by HPLC-MS/MS. The obtained data were analyzed using robust linear regression with Huber's M-estimates, and a number of metabolites with correlated content in plasma and CSF was identified. The statistical analysis shows a significant correlation of metabolite content in plasma and CSF samples for the majority of metabolites. Several metabolites were shown to have high correlation in the control samples, but not in the glioma patients. This can be due to the specific metabolic processes in the glioma patients or to the damaged integrity of blood-brain barrier. The results of our study may be useful for the understanding of molecular mechanisms underlying the development of gliomas, as well as for the search of potential biomarkers for the minimally invasive diagnostic procedures of gliomas.

Rogachev A.D. , Alemasov N.A. , Ivanisenko V.A. , Ivanisenko N. , Gaisler E. , Oleshko O.S. , Cheresiz S. , Mishinov S. , Stupak V.V. , Pokrovsky A.G.
Correlation of Metabolic Profiles of Plasma and Cerebrospinal Fluid of High-Grade Glioma Patients

Metabolites. 2021. V.11. N3. 133 . DOI: 10.3390/metabo11030133 WOS Scopus РИНЦ

Full text from publisher

Published online:

Feb 25, 2021

Web of science	WOS:000633870700001
Scopus	2-s2.0-85102735228
Elibrary	46768247
OpenAlex	W3131450525