Synthesis, structure, and cytotoxicity of complexes of zinc(II), palladium(II), and copper(I) chlorides with (-)-camphor thiosemicarbazone

Synthesis, structure, and cytotoxicity of complexes of zinc(II), palladium(II), and copper(I) chlorides with (-)-camphor thiosemicarbazone Full article

Journal

Polyhedron
ISSN: 0277-5387

Output data

Year: 2019, Volume: 163, Pages: 121-130 Pages count : DOI: 10.1016/j.poly.2019.02.020

Tags

Complexes; Thiosemicarbazone; Terpene; Crystal structure; Cytotoxicity

Authors

Kokina Tatyana E. ^1,2 , Glinskaya Ludmila A. ¹ , Sheludyakova Liliya A. ^1,2 , Eremina Yuliya A. ^1,2,3 , Klyushova Lubov S. ³ , Komarov Vladislav Yu ^1,2 , Piryazev Dmitriy A. ¹ , Tkachev Alexey, V ^2,4 , Larionov Stanislav, V ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Nikolaev Inst Inorgan Chem, 3 Acad Lavrentiev Ave, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, 2 Pirogov Str, Novosibirsk 630090, Russia
3	(Данные Web of science) Fed Res Ctr Fundamental & Translat Med, 2 Timakova Str, Novosibirsk 630117, Russia
4	(Данные Web of science) Russian Acad Sci, Siberian Branch, Vorozhtsov Inst Organ Chem, 9 Acad Lavrentiev Ave, Novosibirsk 630090, Russia

Complexes [Zn(L-2)(2)Cl-2], [Pd-2(L-2)(2)Cl-4], and (CuLCI)-C-2, where L-2 is (-)-camphor thiosemicarbazone, were synthesized. The structures of complexes [Zn(L-2)(2)Cl-2] and [Pd-2(L-2)(2)Cl-4] were determined by X-ray diffraction. The crystal structure of complex [Zn(L-2)(2)Cl-2] contains mononuclear molecules with distorted tetrahedral (ZnCl2S2) coordination units and monodentate L-2 ligands. Complex [Pd-2(L-2)(2)Cl-4] has binuclear structure with Pd metal centers linked by L-2 ligands via mu(2)-S atoms. Complex (CuLCI)-C-2, according to IR and NMR spectra contains S and Cl atoms in the coordination sphere of ion Cu+. Complexes [Pd(tsc)Cl-2] and Zn(tsc)(2)Cl-2 (where tsc is thiosemicarbazide) were also obtained to determine the influence of the terpene moiety on cytotoxic properties of these compounds. Mononuclear complex [Pd(tsc)Cl-2] contains an NSCl2 planar square coordination polyhedron, and tsc is a bidentate chelate ligand. The effects of tsc, L-2, and the complexes with tsc and L-2 on viability of the MCF-7 cell line were investigated next. The results showed that tsc and L-2 are nontoxic at the tested concentrations (1-50 mu M). All the complexes exerted a significant dose-dependent cytotoxic effect, whereas complex (CuLCI)-C-2 was found to have the lowest half-maximal inhibitory concentration (IC50). (C) 2019 Elsevier Ltd. All rights reserved.

Kokina T.E. , Glinskaya L.A. , Sheludyakova L.A. , Eremina Y.A. , Klyushova L.S. , Komarov V.Y. , Piryazev D.A. , Tkachev A.V. , Larionov S.V.
Synthesis, structure, and cytotoxicity of complexes of zinc(II), palladium(II), and copper(I) chlorides with (-)-camphor thiosemicarbazone
Polyhedron. 2019. V.163. P.121-130. DOI: 10.1016/j.poly.2019.02.020 WOS Scopus РИНЦ

Published print:

May 1, 2019

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