Synthesis and cytotoxic activity of usnic acid cyanoethyl derivatives

Synthesis and cytotoxic activity of usnic acid cyanoethyl derivatives Full article

Journal

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Output data

Year: 2016, Volume: 65, Number: 2, Pages: 566-569 Pages count : 4 DOI: 10.1007/s11172-016-1338-7

Tags

usnic acid; natural dibenzofurans; cyanoethylation; cytotoxicity

Authors

Rakhmanova M.E. ^1,2 , Luzina O.A. ¹ , Pokrovskii M.A. ² , Pokrovskii A.G. ² , Salakhutdinov N.F. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, 2 Ul Pirogova, Novosibirsk 630090, Russia

Cyanoethyl derivatives of usnic acid (natural lichen metabolite) were prepared. The reaction proceeded as a C-alkylation process via addition of two acrylonitrile molecules. Cytotoxic effect of the synthesized derivatives on the blood tumor cell lines was studied.

Rakhmanova M.E. , Luzina O.A. , Pokrovskii M.A. , Pokrovskii A.G. , Salakhutdinov N.F.
Synthesis and cytotoxic activity of usnic acid cyanoethyl derivatives
Russian Chemical Bulletin. 2016. V.65. N2. P.566-569. DOI: 10.1007/s11172-016-1338-7 WOS Scopus РИНЦ

Рахманова М.Е. , Лузина О.А. , Покровский М.А. , Покровский А.Г. , Салахутдинов Н.Ф.
Синтез цианэтильных производных усниновой кислоты и их цитотоксическая активность
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2016. №2. С.566-569. РИНЦ

Published print:	Feb 1, 2016
Published online:	Nov 8, 2016

Web of science	WOS:000387600700033
Scopus	2-s2.0-85013752290
Elibrary	29484782
OpenAlex	W2552711420