Design and synthesis of new acridone-based nitric oxide fluorescent probe

Design and synthesis of new acridone-based nitric oxide fluorescent probe Full article

Journal

Molecules
, E-ISSN: 1420-3049

Output data

Year: 2021, Volume: 26, Number: 14, Article number : 4340, Pages count : DOI: 10.3390/molecules26144340

Tags

9(10H)acridone; Fluorescent probes; Nitric oxide probes

Authors

Panfilov Mikhail ^1,2 , Chernova Darya ² , Khalfina Irina ^1,2 , Moskalensky Alexander ² , Vorob’ev Aleksey ^1,2

Affiliations

1	Novosibirsk Institute of Organic Chemistry, 9 Lavrentiev Avenue, Novosibirsk, 630090, Russian Federation
2	Department of Physics, Novosibirsk State University, Novosibirsk, 630090, Russian Federation

Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10H)acridone moiety for nitric oxide sensing. 7,8-Diamino-4-carboxy-10-methyl-9(10H)acridone reacts with NO in aqueous media in the presence of O2, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity. The probe was shown to be capable of nitric oxide sensing in living Jurkat cells. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Panfilov M. , Chernova D. , Khalfina I. , Moskalensky A. , Vorob’ev A.
Design and synthesis of new acridone-based nitric oxide fluorescent probe
Molecules. 2021. V.26. N14. 4340 . DOI: 10.3390/molecules26144340 WOS Scopus РИНЦ

Web of science	WOS:000676371800001
Scopus	2-s2.0-85111299095
Elibrary	46951293
OpenAlex	W3186703558