Effective Synthesis of Fluorescently Labeled Morpholino Nucleoside Triphosphate Derivatives

Effective Synthesis of Fluorescently Labeled Morpholino Nucleoside Triphosphate Derivatives Full article

Journal

Nucleosides, Nucleotides and Nucleic Acids
ISSN: 1525-7770 , E-ISSN: 1532-2335

Output data

Year: 2016, Volume: 35, Number: 1, Pages: 32-42 Pages count : DOI: 10.1080/15257770.2015.1114125

Tags

Morpholino nucleosides; triphosphates; fluorescent labeling

Authors

Tarasenko Yuliya V. ¹ , Abramova Tatyana V. ¹ , Mamatuk Viktor I. ² , Silnikov Vladimir N. ^1,3

Affiliations

1	(Данные Web of science) RAS, Inst Chem Biol & Fundamental Med, SB, Lavrentev Ave 8, Novosibirsk, Russia
2	(Данные Web of science) RAS, Inst Organ Chem, SB, Lavrentev Ave 9, Novosibirsk, Russia
3	(Данные Web of science) NanoTech S LLS, Lavrentev Ave 8, Novosibirsk, Russia

Morpholino nucleoside triphosphates (A, U, G, C, T) bearing the active functional amino group tethered to morpholine residue and their fluorescently labeled derivatives were synthesized. All compounds were characterized by H-1, C-13, and P-31 NMR, and mass spectrometry. A possibility of using fluorescently labeled morpholino nucleoside triphosphates as chain terminators in DNA sequencing is discussed.

Tarasenko Y.V. , Abramova T.V. , Mamatuk V.I. , Silnikov V.N.
Effective Synthesis of Fluorescently Labeled Morpholino Nucleoside Triphosphate Derivatives
Nucleosides, Nucleotides and Nucleic Acids. 2016. V.35. N1. P.32-42. DOI: 10.1080/15257770.2015.1114125 WOS Scopus РИНЦ

Published print:	Jan 2, 2016
Published online:	Jan 25, 2016

Web of science	WOS:000370650700003
Scopus	2-s2.0-84958020022
Elibrary	26823843
OpenAlex	W2286953322