Discovery of a new class of antiviral compounds: Camphor imine derivatives

Discovery of a new class of antiviral compounds: Camphor imine derivatives Full article

Journal

European Journal of Medicinal Chemistry
ISSN: 0223-5234 , E-ISSN: 1768-3254

Output data

Year: 2015, Volume: 105, Pages: 263-273 Pages count : DOI: 10.1016/j.ejmech.2015.10.010

Tags

Influenza; Camphor derivatives; Antiviral; Cage compounds

Authors

Sokolova Anastasiya S. ^1,2 , Yarovaya Olga I. ^1,2 , Shernyukov Andrey V. ¹ , Gatilov Yuriy V. ^1,2 , Razumova Yuliya V. ² , Zarubaev Vladimir V. ³ , Tretiak Tatiana S. ³ , Pokrovsky Andrey G. ² , Kiselev Oleg I. ³ , Salakhutdinov Nariman F. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
3	(Данные Web of science) Influenza Res Ctr, Dept Chemotherapy, St Petersburg 197376, Russia

A new class of compounds featuring a camphor moiety has been discovered that exhibits potent inhibitory activity against influenza A(H1N1)pdm09 and A(H5N1) viruses. The synthesized compounds were characterized by spectroscopic analysis; in addition the structures of compound 2 and 14 were elucidated by the X-ray diffraction technique. Structure activity relationship studies have been conducted to identify the 1,7,7-trimethylbicyclo[2.2.1]heptanes2-ylidene group as the key functional group responsible for the observed antiviral activity. The most potent antiviral compound is imine 2 with therapeutic index more than 500. (C) 2015 Elsevier Masson SAS. All rights reserved.

Sokolova A.S. , Yarovaya O.I. , Shernyukov A.V. , Gatilov Y.V. , Razumova Y.V. , Zarubaev V.V. , Tretiak T.S. , Pokrovsky A.G. , Kiselev O.I. , Salakhutdinov N.F.
Discovery of a new class of antiviral compounds: Camphor imine derivatives
European Journal of Medicinal Chemistry. 2015. V.105. P.263-273. DOI: 10.1016/j.ejmech.2015.10.010 WOS Scopus РИНЦ

Published print:

Nov 1, 2015

Web of science	WOS:000364891400018
Scopus	2-s2.0-84944887540
Elibrary	24963073
OpenAlex	W2179174460