Inhibitory properties of nitrogen-containing adamantane derivatives with monoterpenoid fragments against tyrosyl-DNA phosphodiesterase 1

Inhibitory properties of nitrogen-containing adamantane derivatives with monoterpenoid fragments against tyrosyl-DNA phosphodiesterase 1 Full article

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Output data

Year: 2015, Volume: 41, Number: 6, Pages: 657-662 Pages count : DOI: 10.1134/S1068162015060199

Tags

diazaadamantane; monoterpene; tyrosyl-DNA phosphodiesterase 1; inhibitor of DNA repair

Authors

Zakharenko A. L. ¹ , Ponomarev K. U. ² , Suslov E. V. ² , Korchagina D. V. ² , Volcho K. P. ^2,3 , Vasil'eva I. A. ¹ , Salakhutdinov N. F. ^2,3 , Lavrik O. I. ^2,3

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
3	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

The compounds containing diazaadamantane and monoterpene moieties have been found to inhibit human purified recombinant tyrosyl-DNA phosphodiesterase 1 (Tdp1), a DNA repair enzyme. Several compounds have been shown to be potent inhibitors of a new structural type. Improved inhibition efficiency has been observed for compounds with longer aliphatic chains and increased flexibility of substituent.

Zakharenko A.L. , Ponomarev K.U. , Suslov E.V. , Korchagina D.V. , Volcho K.P. , Vasil'eva I.A. , Salakhutdinov N.F. , Lavrik O.I.
Inhibitory properties of nitrogen-containing adamantane derivatives with monoterpenoid fragments against tyrosyl-DNA phosphodiesterase 1
Russian Journal of Bioorganic Chemistry. 2015. V.41. N6. P.657-662. DOI: 10.1134/S1068162015060199 WOS Scopus РИНЦ

Published print:	Nov 1, 2015
Published online:	Nov 20, 2015

Web of science	WOS:000365428700013
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