Alkaloids of the Flora of Siberia and Altai. XXI.*5'-(1,2,3-Triazolyl)-Substituted Lappaconitine Derivatives

Alkaloids of the Flora of Siberia and Altai. XXI.*5'-(1,2,3-Triazolyl)-Substituted Lappaconitine Derivatives Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2015, Volume: 51, Number: 6, Pages: 1142-1146 Pages count : DOI: 10.1007/s10600-015-1511-5

Tags

lappaconitine; 1H-1,2,3-triazoles; azides

Authors

Romanov V. E. ^1,2 , Shul'ts E. E. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Natl Res Univ, Novosibirsk 630090, Russia

New derivatives of the diterpene alkaloid lappaconitine containing a 1H-substituted 1,2,3-triazol-4-yl substituent in the anthranilate C-5 (') -position were synthesized via the reaction of 5 (') -ethynyllappaconitine with aromatic or aliphatic azides in the presence of aqueous CuSO4 and sodium ascorbate in DMF. The yields of the 1,4-disubstituted 1,2,3-triazoles were 40-73% and depended on the nature of the azide.

Romanov V.E. , Shul'ts E.E.
Alkaloids of the Flora of Siberia and Altai. XXI.*5'-(1,2,3-Triazolyl)-Substituted Lappaconitine Derivatives
Chemistry of Natural Compounds. 2015. V.51. N6. P.1142-1146. DOI: 10.1007/s10600-015-1511-5 WOS Scopus РИНЦ

Published print:	Nov 1, 2015
Published online:	Nov 11, 2015

Web of science	WOS:000365190200029
Scopus	2-s2.0-84957580365
Elibrary	26954788
OpenAlex	W2243489494