Synthesis and antiviral activity of 1-hydroxy-2-(2-hydroxyphenyl)imidazoles against vaccinia virus

Synthesis and antiviral activity of 1-hydroxy-2-(2-hydroxyphenyl)imidazoles against vaccinia virus Full article

Journal

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Output data

Year: 2019, Volume: 68, Number: 3, Pages: 634-637 Pages count : DOI: 10.1007/s11172-019-2467-6

Tags

1-hydroxyimidazoles; vaccinia virus; antiviral activity; cytotoxicity

Authors

Nikitina P. A. ^1,2 , Bormotov N. I. ³ , Shishkina L. N. ³ , Tikhonov A. Ya. ⁴ , Perevalov V. P. ¹

Affiliations

1	(Данные Web of science) DI Mendeleev Univ Chem Technol Russia, 9 Pl Miusskaya, Moscow 125047, Russia
2	(Данные Web of science) Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28 Ul Vavilova, Moscow 119991, Russia
3	(Данные Web of science) State Res Ctr Virol & Biotechnol VECTOR, Koltsov 630559, Novosibirsk Reg, Russia
4	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, 9 Prosp Akad Lavrentieva, Novosibirsk 630090, Russia

2-(2-Hydroxyplienyl)imidazole derivatives were synthesized and tested for antiviral activity against vaccinia virus in Vero cell culture. 1-Methylimidazole 3-oxides, 1-methoxyimidazoles, and 1H-imidazoles showed no activity, whereas some 1-hydroxyimidazole derivatives hold promise, exhibiting antiviral activity and weak cytotoxicity.

Nikitina P.A. , Bormotov N.I. , Shishkina L.N. , Tikhonov A.Y. , Perevalov V.P.
Synthesis and antiviral activity of 1-hydroxy-2-(2-hydroxyphenyl)imidazoles against vaccinia virus
Russian Chemical Bulletin. 2019. V.68. N3. P.634-637. DOI: 10.1007/s11172-019-2467-6 WOS Scopus РИНЦ

Никитина П.А. , Бормотов Н.И. , Скурат Л.Н. , Тихонов А.Я. , Перевалов В.П.
Синтез и противовирусная активность в отношении вируса осповакцины 1-гидрокси-2-(2-гидроксифенил)имидазолов
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2019. №3. С.634-637. РИНЦ

Published print:	Mar 1, 2019
Published online:	Apr 30, 2019

Web of science	WOS:000466506900027
Scopus	2-s2.0-85065138946
Elibrary	38667509
OpenAlex	W2943724569