Hypolipidemic Berberine Derivatives with a Reduced Aromatic Ring C

Hypolipidemic Berberine Derivatives with a Reduced Aromatic Ring C Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2015, Volume: 51, Number: 5, Pages: 916-922 Pages count : DOI: 10.1007/s10600-015-1447-9

Tags

berberine; isoquinoline alkaloids; tetrahydroisoquinoline; LDL receptors; Triton WR1339-induced hypercholesterolemia; hypolipidemic activity

Authors

Nechepurenko I. V. ¹ , Boyarskikh U. A. ² , Khvostov M. V. ¹ , Baev D. S. ¹ , Komarova N. I. ¹ , Filipenko M. L. ² , Tolstikova T. G. ¹ , Salakhutdinov N. F. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk 630090, Russia

A series of aromatic and reduced berberine derivatives were synthesized. Their hypocholesterolemic activity was studied in vitro and in vivo. As a rule, berberine derivatives containing a reduced ring C were more capable of increasing the LDL receptor gene expression than the corresponding aromatic derivatives. Tests using a Triton WR1339-induced hypercholesterolemia model showed that 9-O-tosyltetrahydroberberine and 12-bromotetrahydroberberine possessed pronounced hypocholesterolemic activity and reduced the total cholesterol level by 33 and 27%; the triglyceride level, by 25 and 26%, respectively.

Nechepurenko I.V. , Boyarskikh U.A. , Khvostov M.V. , Baev D.S. , Komarova N.I. , Filipenko M.L. , Tolstikova T.G. , Salakhutdinov N.F.
Hypolipidemic Berberine Derivatives with a Reduced Aromatic Ring C
Chemistry of Natural Compounds. 2015. V.51. N5. P.916-922. DOI: 10.1007/s10600-015-1447-9 WOS Scopus РИНЦ

Published print:	Sep 1, 2015
Published online:	Oct 5, 2015

Web of science	WOS:000362904300025
Scopus	2-s2.0-84950236565
Elibrary	26796443
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