Synthesis and biological activity of novel deoxycholic acid derivatives

Synthesis and biological activity of novel deoxycholic acid derivatives Full article

Journal

Bioorganic and Medicinal Chemistry
ISSN: 0968-0896 , E-ISSN: 1464-3391

Output data

Year: 2015, Volume: 23, Number: 15, Pages: 5022-5034 Pages count : DOI: 10.1016/j.bmc.2015.05.012

Tags

Bile acids; Deoxycholic acid derivatives; Cytotoxicity; Nitric oxide; Biological activity

Authors

Popadyuk Irina I. ¹ , Markov Andrey V. ² , Salomatina Oksana V. ¹ , Logashenko Evgeniya B. ² , Shernyukov Andrey V. ¹ , Zenkova Marina A. ² , Salakhutdinov Nariman F. ^1,3

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia
3	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

We report the synthesis and biological activity of new semi-synthetic derivatives of naturally occurring deoxycholic acid (DCA) bearing 2-cyano-3-oxo-1-ene, 3-oxo-1(2)-ene or 3-oxo-4(5)-ene moieties in ring A and 12-oxo or 12-oxo-9(11)-ene moieties in ring C. Bioassays using murine macrophage-like cells and tumour cells show that the presence of the 9(11)-double bond associated with the increased polarity of ring A or with isoxazole ring joined to ring A, improves the ability of the compounds to inhibit cancer cell growth. (C) 2015 Elsevier Ltd. All rights reserved.

Popadyuk I.I. , Markov A.V. , Salomatina O.V. , Logashenko E.B. , Shernyukov A.V. , Zenkova M.A. , Salakhutdinov N.F.
Synthesis and biological activity of novel deoxycholic acid derivatives
Bioorganic and Medicinal Chemistry. 2015. V.23. N15. P.5022-5034. DOI: 10.1016/j.bmc.2015.05.012 WOS Scopus РИНЦ

Published print:

Aug 1, 2015

Web of science	WOS:000358440000093
Scopus	2-s2.0-84937513123
Elibrary	23991725
OpenAlex	W2236053983