Genotoxic and mutagenic properties of synthetic betulinic acid and betulonic acid

Genotoxic and mutagenic properties of synthetic betulinic acid and betulonic acid Full article

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Output data

Year: 2015, Volume: 41, Number: 4, Pages: 409-413 Pages count : DOI: 10.1134/S1068162015040056

Tags

betulinic acid; betulonic acid; mutagenicity; genotoxicity; Ames test; SOS chromotest

Authors

Frolova T. S. ^1,2 , Kukina T. P. ² , Sinitsyna O. I. ³

Affiliations

1	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk, Russia
3	(Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

Betulinic acid was synthesized from birch bark extract (Betula pendula), with betulonic acid being an intermediate of the synthesis. Both compounds were isolated with a purity of 95%. Genotoxicity and mutagenicity of the prepared compounds was analyzed by the Ames test and SOS chromotest and it was found that the substances show no mutagenic and genotoxic activity.

Frolova T.S. , Kukina T.P. , Sinitsyna O.I.
Genotoxic and mutagenic properties of synthetic betulinic acid and betulonic acid
Russian Journal of Bioorganic Chemistry. 2015. V.41. N4. P.409-413. DOI: 10.1134/S1068162015040056 WOS Scopus РИНЦ

Published print:	Jul 1, 2015
Published online:	Jul 24, 2015

Web of science	WOS:000358415100009
Scopus	2-s2.0-84938086273
Elibrary	23993699
OpenAlex	W2096540085