Acetylenic derivatives of betulonic acid amide as a new type of compounds possessing spasmolytic activity

Acetylenic derivatives of betulonic acid amide as a new type of compounds possessing spasmolytic activity Full article

Journal

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Output data

Year: 2015, Volume: 64, Number: 6, Pages: 1327-1334 Pages count : DOI: 10.1007/s11172-015-1013-4

Tags

triterpenoids; betulonic acid; acetylenes; azides; Mannich bases; 1,3-dipolar cycloadditions; anti-inflammatory activity; hepatoprotective activity; spasmolytic activity

Authors

Govdi A. I. ¹ , Sorokina I. V. ^2,3 , Baev D. S. ² , Bryzgalov A. O. ² , Tolstikova T. G. ^2,4 , Tolstikov G. A. ² , Vasilevsky S. F. ^1,4

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, VV Voevodsky Inst Chem Kinet & Combust, 3 Ul Inst Skaya, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
3	(Данные Web of science) Novosibirsk State Pedag Univ, Novosibirsk 630126, Russia
4	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

Efficient and versatile synthetic procedures towards novel derivatives of betulonic acid via Mannich reaction, Sonogashira cross-coupling, and copper(i)-catalyzed 1,3-dipolar cyclo-additions were developed. Introduction of secondary amines (Mannich reaction) into betulonic acid amides led to derivatives possessing marked spasmolytic activity, which is not characteristic of the triterpene fragment.

Govdi A.I. , Sorokina I.V. , Baev D.S. , Bryzgalov A.O. , Tolstikova T.G. , Tolstikov G.A. , Vasilevsky S.F.
Acetylenic derivatives of betulonic acid amide as a new type of compounds possessing spasmolytic activity
Russian Chemical Bulletin. 2015. V.64. N6. P.1327-1334. DOI: 10.1007/s11172-015-1013-4 WOS Scopus РИНЦ

Говди А.И. , Сорокина И.В. , Баев Д.С. , Брызгалов А.О. , Толстикова Т.Г. , Толстиков Г.А. , Василевский С.Ф.
Ацетиленовые производные амида бетулоновой кислоты - новая группа соединений, обладающих спазмолитической активностью
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2015. №6. С.1327. РИНЦ

Published print:	Jun 1, 2015
Published online:	Feb 27, 2016

Web of science	WOS:000371313900010
Scopus	2-s2.0-84959375742
Elibrary	26972304
OpenAlex	W2341307749