SYNTHESIS AND CYTOTOXIC ACTIVITY OF AZA-MICHAEL REACTION PRODUCTS FROM ETHYL SORBATE AND HETEROCYCLIC AMINES

SYNTHESIS AND CYTOTOXIC ACTIVITY OF AZA-MICHAEL REACTION PRODUCTS FROM ETHYL SORBATE AND HETEROCYCLIC AMINES Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2015, Volume: 51, Number: 2, Pages: 296-301 Pages count : DOI: 10.1007/s10600-015-1264-1

Tags

ethyl sorbate; aza-Michael reaction; cytotoxicity; heterocyclic amines; cancer

Authors

Suslov E. V. ¹ , Korchagina D. V. ¹ , Pokrovskii M. A. ² , Pokrovskii A. G. ² , Volcho K. P. ^1,2 , Salakhutdinov N. F. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

The solvent-free reaction of ethyl sorbate and several heterocyclic amines at room temperature was shown to give aza-Michael 1,4-addition products. The newly formed double bond in the principal product had the E-configuration. It was found that the synthesized compounds exhibited cytotoxicity against cancer cell lines CEM-13, U-937, and MT-4. The piperazine derivative of ethyl sorbate exhibited the greatest activity against cancer cell line U-937, for which the concentration causing 50% death of the tumor cells (CTD50) was 10 mu g/mL.

Suslov E.V. , Korchagina D.V. , Pokrovskii M.A. , Pokrovskii A.G. , Volcho K.P. , Salakhutdinov N.F.
SYNTHESIS AND CYTOTOXIC ACTIVITY OF AZA-MICHAEL REACTION PRODUCTS FROM ETHYL SORBATE AND HETEROCYCLIC AMINES
Chemistry of Natural Compounds. 2015. V.51. N2. P.296-301. DOI: 10.1007/s10600-015-1264-1 WOS Scopus РИНЦ

Published print:	Mar 1, 2015
Published online:	Mar 31, 2015

Web of science	WOS:000352641900019
Scopus	2-s2.0-84953361669
Elibrary	26929361
OpenAlex	W2002656408