A Physicochemical and Pharmacological Study of the Newly Synthesized Complex of Albendazole and the Polysaccharide Arabinogalactan from Larch Wood

A Physicochemical and Pharmacological Study of the Newly Synthesized Complex of Albendazole and the Polysaccharide Arabinogalactan from Larch Wood Full article

Journal

Current Drug Delivery
ISSN: 1567-2018 , E-ISSN: 1875-5704

Output data

Year: 2015, Volume: 12, Number: 5, Pages: 477-490 Pages count : DOI: 10.2174/1567201812666150518094739

Tags

Albendazole; anthelmintic activity; inclusion complexes; increase of water solubility; mechanical activation; NMR-relaxation

Authors

Chistyachenko Yulia S. ¹ , Meteleva Elizaveta S. ¹ , Pakharukova Maria Y. ² , Katokhin Aleksey V. ² , Khvostov Mikhail V. ⁶ , Varlamova Anastasiya I. ⁵ , Glamazdin Igor I. ⁵ , Khalikov Salavat S. ⁴ , Polyakov Nikolay E. ³ , Arkhipov Ivan A. ⁵ , Tolstikova Tatyana G. ⁶ , Mordvinov Viatcheslav A. ² , Dushkin Alexander V. ¹ , Lyakhov Nikolay Z. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Inst Solid State Chem & Mechanochem, Siberian Branch, Novosibirsk 630128, Russia
2	(Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
3	(Данные Web of science) Russian Acad Sci, Inst Chem Kinet & Combust, Siberian Branch, Novosibirsk 630090, Russia
4	(Данные Web of science) Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow, Russia
5	(Данные Web of science) KI Skryabin Sci Res Inst Helminthol, Moscow 117218, Russia
6	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia

Inclusion complexes of albendazole (ABZ) with the polysaccharide arabinogalactan from larch wood Larix sibirica and Larix gmelinii were synthesized using a solid-state mechanochemical technology. We investigated physicochemical properties of the synthesized complexes in the solid state and in aqueous solutions as well as their anthelmintic activity against Trichinella spiralis, Hymenolepis nana, Fasciola hepatica, Opisthorchis felineus, and mixed nematodoses of sheep. Formation of the complexes was demonstrated by means of intrinsic solubility and the NMR relaxation method. The mechanochemically synthesized complexes were more stable in comparison with the complex produced by mixing solutions of the components. The complexes of ABZ showed anthelmintic activity at 10-fold lower doses than did free ABZ. The complexes also showed lower acute toxicity and hepatotoxicity. These results suggest that it is possible to design new drugs on the basis of the ABZ: arabinogalactan complex that are safer and more effective than albendazole.

Chistyachenko Y.S. , Meteleva E.S. , Pakharukova M.Y. , Katokhin A.V. , Khvostov M.V. , Varlamova A.I. , Glamazdin I.I. , Khalikov S.S. , Polyakov N.E. , Arkhipov I.A. , Tolstikova T.G. , Mordvinov V.A. , Dushkin A.V. , Lyakhov N.Z.
A Physicochemical and Pharmacological Study of the Newly Synthesized Complex of Albendazole and the Polysaccharide Arabinogalactan from Larch Wood
Current Drug Delivery. 2015. V.12. N5. P.477-490. DOI: 10.2174/1567201812666150518094739 WOS Scopus РИНЦ

Published print:

Nov 4, 2015

Web of science	WOS:000364532700002
Scopus	2-s2.0-84947941985
Elibrary	24973851
OpenAlex	W304138939