Effect of Acute Administration of 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine Hydrochloride (TC-2153) on Biogenic Amines Metabolism in Mouse Brain

Effect of Acute Administration of 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine Hydrochloride (TC-2153) on Biogenic Amines Metabolism in Mouse Brain Full article

Journal

Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X

Output data

Year: 2015, Volume: 12, Number: 10, Pages: 833-836 Pages count : DOI: 10.2174/1570180812666150522221634

Tags

TC-2153; benzopentathiepine; acute treatment; serotonin; dopamine; brain; mice.

Authors

Kulikova Elizabeth A. ¹ , Bazhenova Ekaterina Y. ¹ , Popova Nina K. ^1,2 , Khomenko Tatyana M. ^2,3 , Volcho Konstantin P. ^2,3 , Salakhutdinov Nariman F. ^2,3 , Kulikov Alexander V. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
3	(Данные Web of science) Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Branch, Novosibirsk 630090, Russia

The brain serotonin (5-HT) and dopamine (DA) systems are targets for many clinically effective antidepressants. Here, we studied the effects of acute administration of a new potential antidepressant drug, 8-(trifluoromethyl)-1,2,3,4,5 - benzopentathiepin-6-amine hydrochloride (TC-2153), on the concentration of 5-HT and DA as well as their main metabolites, 5-hydroxyindoleacetic (5-HIAA) and homovanillic acids (HVA), in the brain. TC-2153 at the doses of 10, 20 or 40 mg/kg was administered by ip injection to adult C57BL/6 mouse males. The levels of 5-HT, 5-HIAA, DA and HVA in the hypothalamus, hippocampus, striatum, midbrain were assayed an hour after treatment using high performance liquid chromatography with electrochemical detection. It was found that 20 and 40 mg/kg of TC-2153 significantly increased 5-HT, 5-HIAA, DA and HVA levels as well as the HVA/DA ratio in the hypothalamus. At the same time, the drug produced no effect on 5-HT, 5-HIAA, DA and HVA levels in the hippocampus, striatum, midbrain or substantia nigra. Therefore, the hypothalamic 5-HT and DA systems are targets for acute TC-2153 injection.

Kulikova E.A. , Bazhenova E.Y. , Popova N.K. , Khomenko T.M. , Volcho K.P. , Salakhutdinov N.F. , Kulikov A.V.
Effect of Acute Administration of 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine Hydrochloride (TC-2153) on Biogenic Amines Metabolism in Mouse Brain
Letters in Drug Design and Discovery. 2015. V.12. N10. P.833-836. DOI: 10.2174/1570180812666150522221634 WOS Scopus РИНЦ

Published print:

Oct 12, 2015

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