Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells Full article
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Bioorganic and Medicinal Chemistry
ISSN: 0968-0896 , E-ISSN: 1464-3391 |
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| Output data | Year: 2014, Volume: 22, Number: 1, Pages: 585-593 Pages count : DOI: 10.1016/j.bmc.2013.10.049 | ||||
| Tags | Glycyrrhetinic acid derivatives; Cytotoxicity; Nitric oxide; Biological activity; Selectivity index | ||||
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Abstract:
Here we report the synthesis and biological activity of new semi-synthetic derivatives of naturally occurring glycyrrhetinic acid bearing a 2-cyano-3-oxo-1-en moiety in the A-ring and double bonds and carbonyl groups in the C, D and E rings. Bioassays using murine macrophage-like and tumor cells show that compound 4, which differs from Soloxolone methyl by the absence of a 9(11)-double bond in the C-ring, displays anti-inflammatory and inhibitory activities with respect to tumor cells with a high selectivity index value. (C) 2013 Elsevier Ltd. All rights reserved.
Cite:
Salomatina O.V.
, Markov A.V.
, Logashenko E.B.
, Korchagina D.V.
, Zenkova M.A.
, Salakhutdinov N.F.
, Vlassov V.V.
, Tolstikov G.A.
Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells
Bioorganic and Medicinal Chemistry. 2014. V.22. N1. P.585-593. DOI: 10.1016/j.bmc.2013.10.049 WOS Scopus РИНЦ OpenAlex
Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells
Bioorganic and Medicinal Chemistry. 2014. V.22. N1. P.585-593. DOI: 10.1016/j.bmc.2013.10.049 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Jan 1, 2014 |
Identifiers:
| Web of science: | WOS:000329068400056 |
| Scopus: | 2-s2.0-84891402001 |
| Elibrary: | 21862240 |
| OpenAlex: | W1978453782 |