Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections Full article
| Journal |
Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171 |
||||||
|---|---|---|---|---|---|---|---|
| Output data | Year: 2019, Volume: 68, Number: 5, Pages: 1041-1046 Pages count : 6 DOI: 10.1007/s11172-019-2517-0 | ||||||
| Tags | Marburg virus; Ebola virus; pseudotyped viruses; (1S)-(+)-camphor-10-sulfonic acid; N-heterocycles; molecular docking | ||||||
| Authors |
|
||||||
| Affiliations |
|
Abstract:
N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.
Cite:
Sokolova A.S.
, Baranova D.V.
, Yarovaya O.I.
, Baev D.S.
, Polezhaeva O.A.
, Zybkina A.V.
, Shcherbakov D.N.
, Tolstikova T.G.
, Salakhutdinov N.F.
Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections
Russian Chemical Bulletin. 2019. V.68. N5. P.1041-1046. DOI: 10.1007/s11172-019-2517-0 WOS Scopus РИНЦ OpenAlex
Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections
Russian Chemical Bulletin. 2019. V.68. N5. P.1041-1046. DOI: 10.1007/s11172-019-2517-0 WOS Scopus РИНЦ OpenAlex
Original:
Соколова А.С.
, Баранова Д.В.
, Яровая О.И.
, Баев Д.С.
, Полежаева О.А.
, Зыбкина А.В.
, Щербаков Д.Н.
, Толстикова Т.Г.
, Салахутдинов Н.Ф.
Синтез производных (1s)-(+)-камфора-10-сульфокислоты и изучение их противовирусной активности в качестве ингибиторов филовирусных инфекций in vitro и in silico
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2019. №5. С.1041-1046. РИНЦ
Синтез производных (1s)-(+)-камфора-10-сульфокислоты и изучение их противовирусной активности в качестве ингибиторов филовирусных инфекций in vitro и in silico
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2019. №5. С.1041-1046. РИНЦ
Dates:
| Published print: | May 1, 2019 |
| Published online: | Jun 11, 2019 |
Identifiers:
| Web of science: | WOS:000471201700015 |
| Scopus: | 2-s2.0-85067183336 |
| Elibrary: | 41633816 |
| OpenAlex: | W2949180311 |