Antidepressant Activity of 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153): Comparison with Classical Antidepressants

Antidepressant Activity of 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153): Comparison with Classical Antidepressants Full article

Journal

Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X

Output data

Year: 2014, Volume: 11, Number: 2, Pages: 169-173 Pages count : 5 DOI: 10.2174/15701808113106660079

Tags

Antidepressants; Benzopentathiepin; Fluoxetine; Iimipramine; Forced swim; Open field; Plus-maze; Mice

Authors

Kulikov Alexander V. ¹ , Tikhonova Maria A. ¹ , Kulikova Elizabeth A. ¹ , Volcho Konstantin P. ² , Khomenko Tatyana M. ² , Salakhutdinov Nariman F. ² , Popova Nina K. ¹

Affiliations

1	Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation
2	Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation

Creation of effective antidepressant drugs is the key problem of the modern neuropharmacology. Here, the effect of acute administration of a new potential psychotropic drug, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153) (10 and 20 mg/kg), on depressive-like behavior in the forced swim test (FST), anxietylike behavior and locomotion in the open field (OFT) and in the elevated plus-maze (PMT) tests was compared with those of classic antidepressant drugs, fluoxetine (20 mg/kg) and imipramine (20 mg/kg). Experiments were performed on adult male mice of AKR. CBA-D13Mit76 recombinant strain. TC-2153 at the doses of 10 or 20 mg/kg as well as fluoxetine and imipramine significantly decreased immobility time in the FST. Both doses of TC-2153 did not alter mouse behavior in the OFT. At the same time, imipramine significantly reduced the distance travelled and the number of rearing bouts, while fluoxetine decreased the number of rearing bouts in the OFT. All drugs produced no effect on the time spent in the center of the OFT and in the open arms in the PMT. These results suggest that TC-2153 is a promising psychotropic drug with the antidepressant-like activity similar to imipramine or fluoxetine, but lacking any visible negative side effect (reduction of locomotion or exploratory behavior).

Kulikov A.V. , Tikhonova M.A. , Kulikova E.A. , Volcho K.P. , Khomenko T.M. , Salakhutdinov N.F. , Popova N.K.
Antidepressant Activity of 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153): Comparison with Classical Antidepressants
Letters in Drug Design and Discovery. 2014. V.11. N2. P.169-173. DOI: 10.2174/15701808113106660079 WOS Scopus РИНЦ OpenAlex

Published print:

Dec 31, 2013

Web of science:	WOS:000331886300007
Scopus:	2-s2.0-84893817063
Elibrary:	21864646
OpenAlex:	W2332126808

DB	Citing
Web of science	19
Scopus	18
Elibrary	23
OpenAlex	23