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Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)-1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model Научная публикация

Журнал Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X
Вых. Данные Год: 2014, Том: 11, Номер: 5, Страницы: 611-617 Страниц : 7 DOI: 10.2174/1570180811666131210000316
Ключевые слова Neuroprotection; Parkinson disease; MPTP; Mice; Monoterpene; Carene; Vanillin
Авторы Pavlova Alla V. 1 , Il'ina Irina V. 1 , Morozova Ekaterina A. 1 , Korchagina Dina V. 1 , Kurbakova Svetlana Yu. 1 , Sorokina Irina V. 1 , Tolstikova Tatyana G. 1 , Volcho Konstantin P. 1 , Salakhutdinov Nariman F. 1
Организации
1 N.N.Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev av., 9, 630090 Novosibirsk, Russian Federation

Реферат: Studies of the neuroprotective activity of a series of monoterpene-derived compounds on the MPTP mice model showed that 4-[(3aR, 7aS)-1,3,3a, 4,5,7a-hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol 15 possessed a considerable neuroprotective activity. Compound 15 was synthesized by one-stage reaction of (+)-2-carene with vanillin. It has low acute toxicity and significantly decreased the development of catalepsy evoked by haloperidol in rats.
Библиографическая ссылка: Pavlova A.V. , Il'ina I.V. , Morozova E.A. , Korchagina D.V. , Kurbakova S.Y. , Sorokina I.V. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)-1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model
Letters in Drug Design and Discovery. 2014. V.11. N5. P.611-617. DOI: 10.2174/1570180811666131210000316 WOS Scopus РИНЦ OpenAlex
Даты:
Опубликована в печати: 9 дек. 2013 г.
Идентификаторы БД:
Web of science: WOS:000335394500009
Scopus: 2-s2.0-84899888576
РИНЦ: 21876919
OpenAlex: W2326172959
Цитирование в БД:
БД Цитирований
Web of science 13
Scopus 12
РИНЦ 13
OpenAlex 14
Альметрики: