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Conjugates of Natural Compounds with Nitroxyl Radicals as a Basis for Creation of Pharmacological Agents of New Generation Научная публикация

Журнал Current Medicinal Chemistry
ISSN: 0929-8673 , E-ISSN: 1875-533X
Вых. Данные Год: 2014, Том: 21, Номер: 24, Страницы: 2839-2852 Страниц : DOI: 10.2174/0929867321666140304153104
Ключевые слова Biological activity; cancer; conjugate; cytotoxicity; nitroxide; nitroxyl radicals; spin-labeled natural compounds; synergistic effect
Авторы Grigor'ev I. A. 1,2 , Tkacheva N. I. 1 , Morozov S. V. 1
Организации
1 (Данные Web of science) Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2 (Данные Web of science) Academician EN Meshalkin State Res Inst Circulat, Novosibirsk 630055, Russia

Реферат: Synthesis and research of pharmacological properties of polyfunctional "hybrid" compounds containing fragments of nitroxyl radicals (NR) in a molecule (spin-labeled conjugates) is a rapidly developing area of medicinal chemistry. Many examples of various classes of natural compounds have shown that the introduction of nitroxyl fragment into a molecule leads to either strengthening of biological activity or its modification, decrease of general toxicity, or increase of selective cytotoxicity. The review of the published data on spin-labeled biologically active natural compounds has revealed that various classes of natural compounds, such as anthracycline antibiotics, lignans, triterpene acids, chromanes, flavonoids, stilbenoids, alkaloids, amino acids, etc. are used for obtaining conjugates with nitroxyl radicals. Some spin-labeled derivatives of natural compounds are used for the treatment and prevention of the most dangerous diseases. Conjugates of nitroxyl radicals with "molecular compasses" (e.g. folic acid, fragments of gramicidin, heparin) may well serve as drug delivery systems to pathological areas of a body for diagnostics and treatment of diseases. We have summarized the results of the last decade on the synthesis and study of biological activity of conjugates with nitroxyl radicals.
Библиографическая ссылка: Grigor'ev I.A. , Tkacheva N.I. , Morozov S.V.
Conjugates of Natural Compounds with Nitroxyl Radicals as a Basis for Creation of Pharmacological Agents of New Generation
Current Medicinal Chemistry. 2014. V.21. N24. P.2839-2852. DOI: 10.2174/0929867321666140304153104 WOS Scopus РИНЦ OpenAlex
Даты:
Опубликована в печати: 31 июл. 2014 г.
Идентификаторы БД:
Web of science: WOS:000338630600009
Scopus: 2-s2.0-84903697243
РИНЦ: 24063885
OpenAlex: W1969678461
Цитирование в БД:
БД Цитирований
Web of science 19
Scopus 17
РИНЦ 23
OpenAlex 20
Альметрики: