Cross-copling reaction to access a library of eudesmane-type methylene lactones with quinoline or isoquinoline substituent Full article
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Journal of Molecular Structure
ISSN: 0022-2860 , E-ISSN: 1872-8014 |
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| Output data | Year: 2022, Volume: 1247, Article number : 131373, Pages count : DOI: 10.1016/j.molstruc.2021.131373 | ||||
| Tags | Cross-coupling reaction; Eudesmane-type methylene lactones; Isoalantolactone; Isoquinoline; Quinoline; X-ray structure | ||||
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Abstract:
An efficient and simple protocol for the Heck reaction of accessible natural eudesmane-type methylene lactone isoalantolactone or its derivatives - 4,15-epoxyisoalantolactone, and 3-hydroxyisoalantolactone, with halosubstituted quinolines and isoquinolines using Pd(OAc)2 as the catalyst is presented. The reactions proceed well in dimethylformamide and TBAB in the absence of phosphine ligands. The structures of isoalantolactone-quinoline and isoalantolactone-isoquinoline hybrids were analyzed by mass spectrum, elemental analysis and NMR spectral studies. The crystal structure of new compounds was determined from single crystal X-ray diffraction data. © 2021 Elsevier B.V.
Cite:
Stepanova V.A.
, Patrushev S.S.
, Rybalova T.V.
, Shults E.E.
Cross-copling reaction to access a library of eudesmane-type methylene lactones with quinoline or isoquinoline substituent
Journal of Molecular Structure. 2022. V.1247. 131373 . DOI: 10.1016/j.molstruc.2021.131373 WOS Scopus РИНЦ OpenAlex
Cross-copling reaction to access a library of eudesmane-type methylene lactones with quinoline or isoquinoline substituent
Journal of Molecular Structure. 2022. V.1247. 131373 . DOI: 10.1016/j.molstruc.2021.131373 WOS Scopus РИНЦ OpenAlex
Identifiers:
| Web of science: | WOS:000704359900017 |
| Scopus: | 2-s2.0-85114128429 |
| Elibrary: | 47051095 |
| OpenAlex: | W3196402499 |