Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice Full article
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Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 |
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| Output data | Year: 2014, Volume: 157, Number: 4, Pages: 506-509 Pages count : DOI: 10.1007/s10517-014-2602-1 | ||||||
| Tags | Ehrlich tumor; inhibitors of indoleamine 2,3-dioxygenase; cytostatic treatment | ||||||
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Abstract:
Ethyl pyruvate, an inhibitor of indoleamine 2,3-dioxygenase, slightly suppressed the growth of transplantable Ehrlich tumor in mice and signifi cantly potentiated the therapeutic effect of cyclophosphamide. Another inhibitor amidoxime produced a similar effect. However, both ethyl pyruvate and amidoxime signifi cantly reduced the effect of cycloplatam therapy. The observed changes can be stipulated by different effects of cyclophosphamide and cycloplatam on the subpopulations of lymphoid cells taking part in the formation of antitumor immunity and resistance to tumors.
Cite:
Bogdanova L.A.
, Morozkova T.S.
, Amitina S.A.
, Mazhukin D.G.
, Nikolin V.P.
, Popova N.A.
, Kaledin V.I.
Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice
Bulletin of Experimental Biology and Medicine. 2014. V.157. N4. P.506-509. DOI: 10.1007/s10517-014-2602-1 WOS Scopus РИНЦ OpenAlex
Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice
Bulletin of Experimental Biology and Medicine. 2014. V.157. N4. P.506-509. DOI: 10.1007/s10517-014-2602-1 WOS Scopus РИНЦ OpenAlex
Original:
Богданова Л.А.
, Морозкова Т.С.
, Амитина С.А.
, Мажукин Д.Г.
, Николин В.П.
, Попова Н.А.
, Каледин В.И.
Двойственное влияние ингибиторов индоламин-2,3-диоксигеназы на терапевтическое действие циклофосфана и циклоплатама в отношении асцитной опухоли эрлиха у мышей
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2014. Т.157. №4. С.507-510. РИНЦ
Двойственное влияние ингибиторов индоламин-2,3-диоксигеназы на терапевтическое действие циклофосфана и циклоплатама в отношении асцитной опухоли эрлиха у мышей
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2014. Т.157. №4. С.507-510. РИНЦ
Dates:
| Published print: | Aug 1, 2014 |
| Published online: | Aug 12, 2014 |
Identifiers:
| Web of science: | WOS:000340661000025 |
| Scopus: | 2-s2.0-84927961791 |
| Elibrary: | 24951899 |
| OpenAlex: | W2123374052 |