Azaadamantanes, a New Promising Scaffold for Medical Chemistry Full article
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Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620 |
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| Output data | Year: 2021, Volume: 47, Number: 6, Pages: 1133-1154 Pages count : 22 DOI: 10.1134/S1068162021060236 | ||
| Tags | antimicrobial activity; antitumor activity; antiviral activity; biological activity; diazaadamantanes; medicinal chemistry; pharmacology; rigit compounds; triazaadamantanes | ||
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Abstract:
Abstract: Azaadamantanes are nitrogen-containing analogs of adamantane, which contain one or more nitrogen atoms instead of carbon atoms. This substitution leads to several specific chemical and physical properties. The azaadamantane derivatives have less lipophilicity compared to their adamantane analogs, which affects both their interaction with biological targets and bioavailability. The significant increase in the number of publications during the last decade (2009–2020) concerning the study of reactivity and biological activity of azaadamantanes and their derivatives indicates a great theoretical and practical interest in these compounds. Compounds with pronounced biological activity have been already discovered among azaadamantane derivatives. The review is devoted to the biological activity of azaadamantanes and their derivatives. It presents the main methods for the synthesis of di- and triazaadamantanes and summarizes the accumulated data on studying the biological activity of these compounds. The prospects for the use of azaadamantanes in medical chemistry and pharmacology are discussed. © 2021, Pleiades Publishing, Ltd.
Cite:
Suslov E.V.
, Ponomarev K.Y.
, Volcho K.P.
, Salakhutdinov N.F.
Azaadamantanes, a New Promising Scaffold for Medical Chemistry
Russian Journal of Bioorganic Chemistry. 2021. V.47. N6. P.1133-1154. DOI: 10.1134/S1068162021060236 WOS Scopus РИНЦ OpenAlex
Azaadamantanes, a New Promising Scaffold for Medical Chemistry
Russian Journal of Bioorganic Chemistry. 2021. V.47. N6. P.1133-1154. DOI: 10.1134/S1068162021060236 WOS Scopus РИНЦ OpenAlex
Original:
Суслов Е.В.
, Пономарев К.Ю.
, Волчо К.П.
, Салахутдинов Н.Ф.
АЗААДАМАНТАНЫ – НОВЫЙ ПЕРСПЕКТИВНЫЙ КАРКАСНЫЙ БЛОК ДЛЯ МЕДИЦИНСКОЙ ХИМИИ И ФАРМАКОЛОГИИ
Биоорганическая химия (RUSS J BIOORG CHEM+). 2021. Т.47. №6. С.659-682. DOI: 10.31857/S0132342321060233 РИНЦ OpenAlex
АЗААДАМАНТАНЫ – НОВЫЙ ПЕРСПЕКТИВНЫЙ КАРКАСНЫЙ БЛОК ДЛЯ МЕДИЦИНСКОЙ ХИМИИ И ФАРМАКОЛОГИИ
Биоорганическая химия (RUSS J BIOORG CHEM+). 2021. Т.47. №6. С.659-682. DOI: 10.31857/S0132342321060233 РИНЦ OpenAlex
Identifiers:
| Web of science: | WOS:000730964700002 |
| Scopus: | 2-s2.0-85121452214 |
| Elibrary: | 47546780 |
| OpenAlex: | W4200222817 |