Hepatoprotective Effect of a New FFAR1 Agonist—N-Alkylated Isobornylamine Full article
| Journal |
Molecules
, E-ISSN: 1420-3049 |
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|---|---|---|---|
| Output data | Year: 2023, Volume: 28, Number: 1, Pages: 396 Pages count : 1 DOI: 10.3390/molecules28010396 | ||
| Tags | hepatoprotective effect; bornyl derivatives; FFAR1 agonist; carbon tetrachloride; liver injury | ||
| Authors |
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| Affiliations |
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Funding (1)
| 1 | Российский Научный Фонд | 21-73-00246 |
Abstract:
Free fatty acid receptor-1 (FFAR1) is one of the possible therapeutic targets in the search
for new hepatoprotective drugs. FFAR1 agonists were found to have hypolipidemic, antifibrotic,
anti-inflammatory, antiproliferative and antioxidant effects in addition to hypoglycemic action. In
this work, we conducted a study of the hepatoprotective effect of the compound QS-528 (previously
discovered as an agonist of FFAR1) at doses of 60, 90, 120 and 150 mg/kg on carbon tetrachloride
(CCl4
)-induced liver injury. At the end of the experiment, a biochemical blood assay demonstrated
that the introduction of QS-528 dose-dependently reduces the levels of liver enzymes (AST, ALT
and ALKP). Histological and morphometric studies of animals’ livers treated with QS-528 at doses
of 120 and 150 mg/kg showed a decrease in degenerative/necrotic changes in hepatocytes and
an increase in the regenerative activity of the liver. In addition, no toxicity at a single oral dose
of 1000 mg/kg and an increase in HepG2 cell viability in vitro were found. Thus, the compound
QS-528 was found to exhibit a hepatoprotective effect against CCl4
-induced toxic liver damage.
Cite:
Pon`kina D.
, Kuranov S.
, Khvostov M.
, Zhukova N.
, Meshkova Y.
, Marenina M.
, Luzina O.
, Tolstikova T.
, Salakhutdinov N.
Hepatoprotective Effect of a New FFAR1 Agonist—N-Alkylated Isobornylamine
Molecules. 2023. V.28. N1. P.396. DOI: 10.3390/molecules28010396 WOS Scopus РИНЦ OpenAlex
Hepatoprotective Effect of a New FFAR1 Agonist—N-Alkylated Isobornylamine
Molecules. 2023. V.28. N1. P.396. DOI: 10.3390/molecules28010396 WOS Scopus РИНЦ OpenAlex
Dates:
| Submitted: | Dec 14, 2022 |
| Published print: | Jan 3, 2023 |
| Accepted: | Dec 29, 2023 |
Identifiers:
| Web of science: | WOS:000910154900001 |
| Scopus: | 2-s2.0-85145688178 |
| Elibrary: | 60331791 |
| OpenAlex: | W4313432992 |