Abstract: The effects of two derivatives of 2-aminoadamantane, enantiomers J447H and J579, on the behavior of male and female C57Bl/6J mice were studied using a modified light/dark test. The substances differed by their effects on the behavior of male mice. J579 reduced the number of rearings. J447H in a dose of 1 mg/kg affected more parameters: it reduced exploratory activity 1 h after administration and stimulated exploratory and motor activity in 2 h. In female mice, J447H significantly reduced the number of peepings into holes in 2 h after administration. The results indicate that further analysis of the effects of J579 and especially J447H is required.

Cite: Avgustinovich D.F. , Fomina M.K. , Suslov E.V. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
Effect of 2-Aminoadamantane Derivatives on Behavior of Mice in a Modified Light/Dark Test
Bulletin of Experimental Biology and Medicine. 2014. V.158. N2. P.213-218. DOI: 10.1007/s10517-014-2725-4 WOS Scopus РИНЦ OpenAlex

Original: Августинович Д.Ф. , Маренина М.К. , Суслов Е.В. , Толстикова Т.Г. , Волчо К.П. , Салахутдинов Н.Ф.
Исследование влияния производных 2-аминоадамантана на поведение мышей в модернизированном тесте "свет--темнота"
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2014. Т.158. №8. С.177-182. РИНЦ

Dates:

Published online:	Nov 29, 2014
Published print:	Dec 1, 2014

Identifiers:

Web of science:	WOS:000346635800010
Scopus:	2-s2.0-84939933669
Elibrary:	22775344
OpenAlex:	W1985214511

Citing:

DB	Citing
Web of science	4
Scopus	4
OpenAlex	4

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