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Synthesis of Norabietyl and Nordehydroabietyl Imidazolidine-2,4,5-Triones and Their Activity against Tyrosyl-DNA Phosphodiesterase 1 Научная публикация

Журнал MolBank
ISSN: 1422-8599
Вых. Данные Год: 2023, Том: 2023, Номер: 4, Страницы: M1743 Страниц : DOI: 10.3390/m1743
Ключевые слова resin acids; TDP1 inhibitors; heterocyclic compounds; DNA repair; parabanic acid; adamantane; dehydroabietic acid; abietic acid
Авторы Kovaleva Kseniya S. 1 , Yarovaya Olga I. 1 , Chernyshova Irina A. 2 , Zakharenko Alexandra L. 2 , Cheresiz Sergey V. 3 , Azimirad Amirhossein 3 , Pokrovsky Andrey G. 3 , Lavrik Olga I. 2 , Salakhutdinov Nariman F. 1
Организации
1 N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
2 Institute of Chemical Biology and Fundamental Medicine SB RAS
3 Novosibirsk State University

Информация о финансировании (1)

1 Российский Научный Фонд
Министерство науки и инновационной политики Новосибирской области 		23-23-10077

Реферат: New imidazolidine-2,4,5-triones with norabietic, nordehydroabietic, and adamantane substituents were synthesized by reacting oxalyl chloride and the corresponding ureas, providing good yields. Bioisosteric replacement of the ureide group with a parabanic acid fragment made it possible to increase the solubility of compounds and conduct biological studies. The compounds inhibit the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 in submicromolar concentrations. Cytotoxic concentrations were also studied on the glioblastoma cell line SNB19.
Библиографическая ссылка: Kovaleva K.S. , Yarovaya O.I. , Chernyshova I.A. , Zakharenko A.L. , Cheresiz S.V. , Azimirad A. , Pokrovsky A.G. , Lavrik O.I. , Salakhutdinov N.F.
Synthesis of Norabietyl and Nordehydroabietyl Imidazolidine-2,4,5-Triones and Their Activity against Tyrosyl-DNA Phosphodiesterase 1
MolBank. 2023. V.2023. N4. P.M1743. DOI: 10.3390/m1743 WOS Scopus РИНЦ OpenAlex
Даты:
Поступила в редакцию: 19 окт. 2023 г.
Принята к публикации: 7 нояб. 2023 г.
Опубликована в печати: 9 нояб. 2023 г.
Идентификаторы БД:
Web of science: WOS:001130831300001
Scopus: 2-s2.0-85180686638
РИНЦ: 63938775
OpenAlex: W4388524215
Цитирование в БД:
БД Цитирований
OpenAlex 2
Web of science 2
Альметрики: