Sciact
  • EN
  • RU

Inhibitors of the RBD-ACE-2 Found among a Wide Range of Dyes by the Immunoassay Method Научная публикация

Журнал Chemosensors
ISSN: 2227-9040
Вых. Данные Год: 2023, Том: 11, Номер: 2, Страницы: 135 Страниц : 1 DOI: 10.3390/chemosensors11020135
Ключевые слова SARS-CoV-2 virus; spike S; ELISA; RBD; dyes
Авторы Mordvinova Ekaterina D. 1,2 , Nikitina Polina A. 3 , Yarovaya Olga I. 1 , Volosnikova Ekaterina A. 2 , Murashkin Denis E. 2 , Isaeva Anastasiya A. 2 , Koldaeva Tatiana Y. 3 , Perevalov Valery P. 3 , Salakhutdinov Nariman F. 1 , Shcherbakov Dmitriy N. 2
Организации
1 N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
2 State Research Center of Virology and Biotechnology VECTOR
3 D. Mendeleyev University of Chemical Technology of Russia

Реферат: Angiotensin-converting enzyme 2 (ACE2), the functional receptor of SARS-CoV-2, plays a crucial role in the pathogenesis of COVID-19. ACE2 targeting holds the promise for preventing and inhibiting SARS-CoV-2 infection. In this work, we describe the development and use of a test system based on competitive ELISA for the primary screening of potential antiviral compounds. We studied the activity of the library of dyes of different groups. Several dyes (ortho-cresolphthalein, eosin (free acid), eosin (Na salt)) that inhibited the interaction of ACE2 with the spike proteins of SARS-CoV-2 have been identified among the candidates. A potential antiviral drug, methylene blue, did not show activity in our study. We believe that our results can help in the further search for inhibitors of interaction between the coronavirus spike protein and ACE2 receptor.
Библиографическая ссылка: Mordvinova E.D. , Nikitina P.A. , Yarovaya O.I. , Volosnikova E.A. , Murashkin D.E. , Isaeva A.A. , Koldaeva T.Y. , Perevalov V.P. , Salakhutdinov N.F. , Shcherbakov D.N.
Inhibitors of the RBD-ACE-2 Found among a Wide Range of Dyes by the Immunoassay Method
Chemosensors. 2023. V.11. N2. P.135. DOI: 10.3390/chemosensors11020135 WOS Scopus РИНЦ OpenAlex
Даты:
Поступила в редакцию: 25 дек. 2022 г.
Принята к публикации: 10 февр. 2023 г.
Опубликована в печати: 13 февр. 2023 г.
Идентификаторы БД:
Web of science: WOS:000938929200001
Scopus: 2-s2.0-85148878043
РИНЦ: 60696500
OpenAlex: W4320490888
Цитирование в БД:
БД Цитирований
OpenAlex 1
Web of science 1
Scopus 1
Альметрики: