Antiparkinsonian activity of some 9-N-, O-, S- and C-derivatives of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol

Antiparkinsonian activity of some 9-N-, O-, S- and C-derivatives of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol Научная публикация

Журнал

Bioorganic and Medicinal Chemistry
ISSN: 0968-0896 , E-ISSN: 1464-3391

Вых. Данные

Год: 2013, Том: 21, Номер: 5, Страницы: 1082-1087 Страниц : DOI: 10.1016/j.bmc.2013.01.003

Ключевые слова

(1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol; Monoterpenoid; Derivatives; Antiparkinsonian activity; MPTP model; Mice

Авторы

Ardashov Oleg V. ¹ , Pavlova Alla V. ¹ , Korchagina Dina V. ¹ , Volcho Konstantin P. ¹ , Tolstikova Tat'yana G. ¹ , Salakhutdinov Nariman F. ¹

Организации

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia

Earlier it was found, that (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol (1) possess high antiparkinsonian activity. The N-, O-, S- and C-derivatives at the C-9 position of diol 1 were synthesized in this work. The antiparkinsonian activity of these compounds was studied in MPTP mice models. As a rule, the introduction of substituents containing nitrogen atoms at the C-9 position led to a considerable decrease or loss of antiparkinsonian activity. A derivative of 2-aminoadamantane 8 significantly decreased the locomotor activity time, thus enhancing the symptoms of the parkinsonian syndrome. However the introduction of butyl or propylthio substituents at the C-9 position of diol 1 did not diminish the antiparkinsonian activity comparing to parent compound. This information is important when choosing a route for immobilization of compound 1 to find possible targets. (C) 2013 Elsevier Ltd. All rights reserved.

Ardashov O.V. , Pavlova A.V. , Korchagina D.V. , Volcho K.P. , Tolstikova T.G. , Salakhutdinov N.F.
Antiparkinsonian activity of some 9-N-, O-, S- and C-derivatives of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol
Bioorganic and Medicinal Chemistry. 2013. V.21. N5. P.1082-1087. DOI: 10.1016/j.bmc.2013.01.003 WOS Scopus РИНЦ OpenAlex

Опубликована в печати:

1 мар. 2013 г.

Web of science:	WOS:000314689200006
Scopus:	2-s2.0-84873743106
РИНЦ:	20433729
OpenAlex:	W2056014369

БД	Цитирований
Web of science	16
Scopus	16
РИНЦ	21
OpenAlex	17