Synthesis of 1,2,3-Triazolyl-Substituted Derivatives of the Alkaloids Sinomenine and Tetrahydrothebaine on Ring A and Their Analgesic Activity Full article
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Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388 |
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| Output data | Year: 2022, Volume: 58, Number: 5, Pages: 895-902 Pages count : 8 DOI: 10.1007/s10600-022-03824-5 | ||
| Tags | alkaloids triazoles azide–alkyne cycloaddition reaction analgesic activity | ||
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Abstract:
The isoquinoline alkaloids 4-O-methylsinomenine and C-annelated tetrahydrothebaine were modified by addition of 1,2,3-triazolyl substituents in the C-1 position of the morphinane skeleton via a Cu-catalyzed reaction of 1-ethynyl-substituted alkaloid derivatives with various azides. Analgesic activity in a chemical irritation model was found for 1-triazolyl-substituted derivatives of 6,7,8,14-tetrahydrothebaine.
Cite:
Finke A.O.
, Pavlova A.V.
, Morozova E.A.
, Tolstikova T.G.
, Shults E.E.
Synthesis of 1,2,3-Triazolyl-Substituted Derivatives of the Alkaloids Sinomenine and Tetrahydrothebaine on Ring A and Their Analgesic Activity
Chemistry of Natural Compounds. 2022. V.58. N5. P.895-902. DOI: 10.1007/s10600-022-03824-5 WOS РИНЦ OpenAlex
Synthesis of 1,2,3-Triazolyl-Substituted Derivatives of the Alkaloids Sinomenine and Tetrahydrothebaine on Ring A and Their Analgesic Activity
Chemistry of Natural Compounds. 2022. V.58. N5. P.895-902. DOI: 10.1007/s10600-022-03824-5 WOS РИНЦ OpenAlex
Dates:
| Submitted: | Apr 1, 2022 |
| Published online: | Sep 23, 2022 |
Identifiers:
| Web of science: | WOS:000857281700008 |
| Elibrary: | 51560931 |
| OpenAlex: | W4297017265 |