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Synthesis and analgesic activity of alkyl-substituted octahydro-2H-chromenols Full article

Journal Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171
Output data Year: 2022, Volume: 71, Number: 11, Pages: 2482-2488 Pages count : 7 DOI: 10.1007/s11172-022-3677-x
Tags monoterpenes montmorillonite K10 heterocyclic compounds analgesic activity
Authors Il’ina I.V. 1 , Korchagina D.V. 1 , Morozova E.A. 1 , Tolstikova T.G. 1 , Volcho K.P. 1 , Salakhutdinov N.F. 1
Affiliations
1 N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences

Abstract: A series of new compounds with hydrogenated 2H-chromene framework was synthesized starting from aliphatic aldehydes and available p-menthane monoterpenoid (−)-isopulegol in the presence of montmorillonite K10. These compounds were formed as a pair of diastereoisomers, which were isolated individually using column chromatography. Some of the compounds obtained were found to exhibit high analgesic activity in in vivo tests.
Cite: Il’ina I.V. , Korchagina D.V. , Morozova E.A. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
Synthesis and analgesic activity of alkyl-substituted octahydro-2H-chromenols
Russian Chemical Bulletin. 2022. V.71. N11. P.2482-2488. DOI: 10.1007/s11172-022-3677-x WOS Scopus РИНЦ OpenAlex
Original: Ильина И.В. , Корчагина Д.В. , Морозова Е.А. , Толстикова Т.Г. , Волчо К.П. , Салахутдинов Н.Ф.
Синтез и изучение анальгетической активности алкилзамещенных октагидро-2H-хроменолов
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2022. №11. С.2482–2488.
Dates:
Submitted: May 30, 2022
Accepted: Aug 30, 2022
Published online: Dec 19, 2022
Identifiers:
Web of science: WOS:000921286500020
Scopus: 2-s2.0-85144275869
Elibrary: 52057647
OpenAlex: W4311944130
Citing:
DB Citing
OpenAlex 8
Web of science 9
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