Antitumor activity of amides of dihydrobetulonic acid in vitro and in vivo Full article
| Journal |
Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620 |
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| Output data | Year: 2013, Volume: 39, Number: 2, Pages: 194-201 Pages count : DOI: 10.1134/S106816201302012X | ||||||
| Tags | dihydrobetulonic acid; amides; piperazine derivatives; antitumor activity; antimetastatic effect | ||||||
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Abstract:
Amides containing homopiperidine and piperazine cycles were synthesized from dihydrobetulonic acid obtained by the oxidation of dihydrobetulin. All substances were shown to have a high antitumor activity (CCID50 = 3.5-36.2 mu M) in vitro in lymphoid (CEM-13, U-937) and monocytic (MT-4) human cell lines. Amides containing the methyl- and ethylpiperazine residues do not influence the viability of Lung Lewis Carcinoma cells in culture and do not have a significant effect on its transplants in C57BL/6 mice. However, these amides efficiently inhibit the development of metastases in lungs of these mice. The antimetastatic activity of the studied amides increases with changing the methyl by ethyl aliphatic residue in the piperazine cycle.
Cite:
Sorokina I.V.
, Mainagashev I.Y.
, Zhukova N.A.
, Korchagina D.V.
, Tolstikova T.G.
, Nikolin V.P.
, Popova N.A.
, Pokrovskii M.A.
, Pokrovskii A.G.
, Salakhutdinov N.F.
Antitumor activity of amides of dihydrobetulonic acid in vitro and in vivo
Russian Journal of Bioorganic Chemistry. 2013. V.39. N2. P.194-201. DOI: 10.1134/S106816201302012X WOS Scopus РИНЦ OpenAlex
Antitumor activity of amides of dihydrobetulonic acid in vitro and in vivo
Russian Journal of Bioorganic Chemistry. 2013. V.39. N2. P.194-201. DOI: 10.1134/S106816201302012X WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Mar 1, 2013 |
| Published online: | Mar 22, 2013 |
Identifiers:
| Web of science: | WOS:000316686600011 |
| Scopus: | 2-s2.0-84880717884 |
| Elibrary: | 20446616 |
| OpenAlex: | W2045066995 |