Synthesis and evaluation of antibacterial activity of bis-eudesmanolides connected by nitrogen-containing linkers Full article
| Journal |
Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171 |
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| Output data | Year: 2023, Volume: 72, Number: 10, Pages: 2513-2524 Pages count : 12 DOI: 10.1007/s11172-023-4054-0 | ||||||
| Tags | sesquiterpenoids isoalantolactone bis-eudesmanolides diamines azides 1,2,3-triazoles Michael reaction azide-alkyne cycloaddition antibacterial activity | ||||||
| Authors |
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| Affiliations |
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Funding (1)
| 1 | Российский Научный Фонд | 23-73-00077 |
Abstract:
The reaction of isoalantolactone with primary amines or piperazine proceeds under mild conditions with high stereoselectivity to give 11,13-isoalantolactone dimers connected by an alkyldiamine or piperazine linker. The reaction of isoalantolactone with propargylamine hydrochloride afforded the corresponding 13-propargylamino-11,13-dihydroisoalantolactone or 13-propargylamino-N-bis(11,13-dihydroisoalantolactone). The synthesized propargylamines showed high activity in the Cu-catalyzed cycloaddition with organic azides. The newly synthesized compounds with a bis-eudesman structure were found to exhibit antibacterial activity against strains of Staphylococcus aureus, Bacillus cereus, and Escherichia coli.
Cite:
Patrushev S.S.
, Vasil’eva D.O.
, Burova L.G.
, Bondareva E.A.
, Zakharova L.N.
, Evstropov A.N.
, Shults E.E.
Synthesis and evaluation of antibacterial activity of bis-eudesmanolides connected by nitrogen-containing linkers
Russian Chemical Bulletin. 2023. V.72. N10. P.2513-2524. DOI: 10.1007/s11172-023-4054-0 WOS Scopus РИНЦ OpenAlex
Synthesis and evaluation of antibacterial activity of bis-eudesmanolides connected by nitrogen-containing linkers
Russian Chemical Bulletin. 2023. V.72. N10. P.2513-2524. DOI: 10.1007/s11172-023-4054-0 WOS Scopus РИНЦ OpenAlex
Original:
Патрушев С.С.
, Васильева Д.О.
, Бурова Л.Г.
, Бондарева Е.А.
, Захарова Л.Н.
, Евстропов А.Н.
, Шульц Э.Э.
Синтез и оценка антибактериальной активности бис-эудесманолидов с азотсодержащими линкерами
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2023. Т.72. №10. С.2513-2524.
Синтез и оценка антибактериальной активности бис-эудесманолидов с азотсодержащими линкерами
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2023. Т.72. №10. С.2513-2524.
Dates:
| Submitted: | May 15, 2023 |
| Accepted: | Jul 7, 2023 |
| Published print: | Nov 11, 2023 |
Identifiers:
| Web of science: | WOS:001103056900029 |
| Scopus: | 2-s2.0-85176144195 |
| Elibrary: | 64003783 |
| OpenAlex: | W4388587032 |